Results 61 to 70 of about 922,615 (281)
Smooth Function Approximation by Deep Neural Networks with General Activation Functions
Entropy, 2019 There has been a growing interest in expressivity of deep neural networks. However, most of the existing work about this topic focuses only on the specific activation function such as ReLU or sigmoid.
Ilsang Ohn, Yongdai Kim
doaj +1 more source
Information Bounds and Convergence Rates for Side-Channel Security Evaluators
Transactions on Cryptographic Hardware and Embedded Systems, 2023 Current side-channel evaluation methodologies exhibit a gap between inefficient tools offering strong theoretical guarantees and efficient tools only offering heuristic (sometimes case-specific) guarantees.
Loïc Masure +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Convergence rates in homogenization of p-Laplace equations
Boundary Value Problems, 2019 This paper is concerned with homogenization of p-Laplace equations with rapidly oscillating periodic coefficients. The main difficulty of this work is due to the nonlinear structure in this field concerning p-Laplace equations itself. Utilizing the layer
Jie Zhao, Juan Wang
doaj +1 more source
Adaptive boundary element methods with convergence rates [PDF]
, 2011 This paper presents adaptive boundary element methods for positive, negative, as well as zero order operator equations, together with proofs that they converge at certain rates.
Gantumur, Tsogtgerel
core
, 2016 We prove convergence rates of explicit finite difference schemes for the linear advection and wave equation in one space dimension with H\"older continuous coefficient.
Weber, Franziska
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Practical drift conditions for subgeometric rates of convergence
, 2004 We present a new drift condition which implies rates of convergence to the stationary distribution of the iterates of a \psi-irreducible aperiodic and positive recurrent transition kernel.
Douc, Randal +3 more
core +5 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source