Results 91 to 100 of about 34,688 (214)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
The study of new fixed-point iteration schemes for solving absolute value equations
HeliyonAbsolute value equations (AVEs) play a crucial role in solving various complexities across scientific computing, engineering, management science, and operations research.
Rashid Ali, Zhao Zhang, Fuad A. Awwad
doaj +1 more source
A Convergence Result for Asynchronous Algorithms and Applications
, 2007 We give in this paper a convergence result concerning parallel asynchronous algorithm with bounded delays to solve a nonlinear fixed point problems. This result is applied to calculate the solution of a strongly monotone operator. Special cases of these operators are used to solve some problems related to convex analysis like minimization of ...
openaire +3 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Convergence results for a class of abstract continuous descent methods
Electronic Journal of Differential Equations, 2004 We study continuous descent methods for the minimization of Lipschitzian functions defined on a general Banach space. We establish convergence theorems for those methods which are generated by approximate solutions to evolution equations governed by ...
Sergiu Aizicovici +2 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Duality arguments for well-posedness of history-dependent variational inequalities
Electronic Journal of Differential Equations, 2022 Rong Hu, Mircea Sofonea
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Certain convergence results for homogeneous singular Young measures
Journal of Applied Mathematics and Computational Mechanics, 2023 Piotr Puchała
doaj +1 more source