Results 31 to 40 of about 34,688 (214)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier   +11 more
wiley   +1 more source

On a class of saddle point problems and convergence results

open access: yesMathematical Modelling and Analysis, 2020
We consider an abstract mixed variational problem consisting of two inequalities. The first one is governed by a functional φ, possibly non-differentiable. The second inequality is governed by a nonlinear term depending on a non negative parameter ǫ.
Mariana Chivu Cojocaru, Andaluzia Matei
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan   +3 more
wiley   +1 more source

Convergence Results on Iteration Algorithms to Linear Systems

open access: yesThe Scientific World Journal, 2014
In order to solve the large scale linear systems, backward and Jacobi iteration algorithms are employed. The convergence is the most important issue. In this paper, a unified backward iterative matrix is proposed.
Zhuande Wang, Chuansheng Yang, Yubo Yuan
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Results on the Existence and Convergence of Best Proximity Points

open access: yesFixed Point Theory and Applications, 2010
We first consider a cyclic φ-contraction map on a reflexive Banach space X and provide a positive answer to a question raised by Al-Thagafi and Shahzad on the existence of best proximity points for cyclic φ-contraction maps in reflexive ...
Ali Abkar, Moosa Gabeleh
doaj   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Notes on Convergence Results for Parabolic Equations with Riemann–Liouville Derivatives

open access: yesMathematics, 2022
Fractional diffusion equations have applications in various fields and in this paper we consider a fractional diffusion equation with a Riemann–Liouville derivative.
Long Le Dinh, O’regan Donal
doaj   +1 more source

A General Convergence Result for Particle Filtering

open access: yesIEEE Transactions on Signal Processing, 2011
The particle filter has become an important tool in solving nonlinear filtering problems for dynamic systems. This correspondence extends our recent work, where we proved that the particle filter converges for unbounded functions, using L4-convergence.
Xiao-Li Hu   +2 more
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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