Results 61 to 70 of about 34,688 (214)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Existence and convergence of fixed point results for noncyclic $\varphi$-contractions [PDF]

AUT Journal of Mathematics and Computing
In the paper, we introduce a new class of noncyclic $\varphi$-contractions as a generalization of the class of noncyclic contractions which was first introduced in the paper [R. Esp\'{i}nola, M.
Akram Safari-Hafshejani
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Some Results on Wijsman Ideal Convergence in Intuitionistic Fuzzy Metric Spaces

Journal of Function Spaces, 2020
In the present work, we study and extend the notion of Wijsman J–convergence and Wijsman J∗–convergence for the sequence of closed sets in a more general setting, i.e., in the intuitionistic fuzzy metric spaces (briefly, IFMS).
Ayhan Esi, Vakeel A. Khan, Mobeen Ahmad, Masood Alam   +3 more
doaj   +1 more source

The discrete Douglas problem: convergence results

IMA Journal of Numerical Analysis, 2005
In her previous paper [``The discrete Douglas problem: Theory and numerics'', Interfaces Free Bound. 6, No. 2, 219--252 (2004; Zbl 1084.53008)], the author defined a general framework to solve the problem of finding and justifying an optimal fully discrete finite-element procedure for approximating annulus-like minimal surfaces.
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Convergence theorems and stability results for Lipschitz strongly pseudocontractive operators

International Journal of Mathematics and Mathematical Sciences, 2002
Suppose that X is an arbitrary real Banach space and T:X→X is a Lipschitz strongly pseudocontractive operator. It is proved that under certain conditions the Ishikawa iterative method with errors converges strongly to the fixed point of T and this ...
Zeqing Liu, Lili Zhang, Shin Min Kang
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source