Results 111 to 120 of about 1,961 (283)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Speech act theory, discourse structure and indirect speech [PDF]
, 1991 Speech Act Theory is concerned with the ways in which language can be used. It originated with Austin, but was developed by Searle. The theories of Austin and Searle are described and several problem areas are identified.
Smith, Peter Wilfred Hesling
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Listening to young children talking on the telephone: a reassessment of Vygotsky's notion of 'egocentric speech'. [PDF]
, 2000 In this article the author explores aspects of young children's private speech, examining characteristics of their development of discourse knowledge in utterances that are not directed to actual conversants.
Gillen, Julia
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Matching across Turns in Talk-in-Interaction: The Role of Prosody and Gesture [PDF]
, 2012 Understanding the design of talk-in-interaction is important in many domains, including speech technology. Although phonetic, linguistic and gestural correlates have been identified for some of the social actions that conversational participants ...
Gorisch, Jan P.F.M.
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From appearings to disengagements: Openings and closings in video-mediated tele-homecare encounters [PDF]
, 2020 In this article, we examine openings and closings in video-mediated tele-homecare for older adults in Finland, using multimodal conversation analysis.
Ilomäki, Sakari, Ruusuvuori, Johanna
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Modelling Speech Acts in Conversational Discourse [PDF]
, 2005 Computational pragmatics and dialogue analysis is currently a rapid growing area of research in computational linguistics. Over the past five years or so, initiatives in modelling pragmatic aspects of dialogue have led to considerably improved spoken ...
Schiffrin, Amanda
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