FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
How parents derive their informed role preferences for end-of-life medical decision-making for (unborn) children in perinatology: a meta-ethnography of qualitative interview studies. [PDF]
BMC Med EthicsKuehlmeyer K +4 more
europepmc +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Investigating Communication Support Strategies as 'Micro-Interventions': A Conceptual-Methodological Framework Applying Realist Evaluation and Relevance Theory. [PDF]
Int J Lang Commun DisordJagoe C, Conica M, Wharton T, Zakaria M.
europepmc +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
What students ask matters: Static and longitudinal questioning patterns in student-LLM dialogue and self-reported cognitive engagement. [PDF]
PLoS OneQu J, Dai L, Yin M.
europepmc +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Nearby, Self-Critical, Ambivalent: Modes of Writing Arab Queerness. [PDF]
Cult Stud Crit MethodolBouqentar L.
europepmc +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Demographics, Clinical Content, Use Patterns, and Care-Seeking Intent Across Two Generations of AI-Enabled Clinical Triage Tools (A Traditional Structured Questionnaire and a Large Language Model-Enabled Conversational Interface): Comparative Retrospective Observational Study. [PDF]
JMIR AIMarecka M +3 more
europepmc +1 more source