Results 91 to 100 of about 1,961 (282)
The ‘questionableness’ of things: opening up the conversation [PDF]
, 2016 The authors show, through its structure and form, what it means to open up a collaborative conversation. This chapter developed from a number of conversations that took place at the Fourth International Conference on Value and Virtue in Practice-Based Research, the twin themes of which were 'openness' and 'criticality'.
Nixon, J. +5 more
openaire +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Opening the conversation: An introduction to open educational resources
Journal of New Librarianship, 2017 This column explores the concept of and issues surrounding Open Educational Resources (OER) for librarians.
openaire +3 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The organization of turns at formal talk in the classroom
, 1978 Beginning with a consideration of some commonsense and professional conceptions of what a formal situation might comprise, this paper goes on to ask the question: where along a linear array which has its poles in exemplars of formal and informal speech ...
McHoul, A.
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Pragmatics and the consequentiality of talk: a study of members' methods at a planning application meeting [PDF]
, 1995 This study explores how talk is consequential by examining the sequential and pragmatic phenomena in talk-in-interaction. Reflecting the work of conversation analysis (CA), the approach assumes that the consequentiality of a 'context' must be ...
Glover, Kelly D., Glover, K.D
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Telephone conversation openings across languages, cultures and settings [PDF]
, 2018 The organization of telephone conversation has received much scholarly attention since Schegloff’s pioneering work in the 1960s and 1970s (Schegloff 1968, 1979). There are several reasons why researchers have been fascinated by telephone conversations in
Márquez Reiter, Rosina +1 more
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Towards debate and open conversation [PDF]
Scandinavian Economic History Review, 2016 Ojala, J., Reckendrees, A.
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source