Results 81 to 90 of about 1,961 (283)
Open Science: A Candid Conversation
In response to concerns about the credibility of many published research findings, open science reforms such as preregistration, data sharing, and alternative forms of publication are being increasingly adopted across scientific communities. Although journals on giftedness and advanced academic research have already implemented several of these ...
Makel , Matthew, Smith , Kendal
openaire +2 more sources
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Uncommon ground: the distribution of dialogue contexts [PDF]
PhDContext in dialogue is at once regarded as a set of resources enabling successful interpretation and is altered by such interpretations. A key problem for models of dialogue, then, is to specify how the shared context evolves.
Eshghi, Arash
core
Clear and Engaging: A Review of Sidnell\u27s Conversation Analysis: An Introduction [PDF]
Conversation Analysis: An Introduction by Jack Sidnell is a concise and clear primer to describing, analyzing, and understanding human talk. Combining theoretical descriptions and analysis of transcribed conversations, Sidnell (2010) explains the ...
Parylo, Oksana
core +2 more sources
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Factors Affecting Conversational Openings In English And Vietnamese [PDF]
The Vietnamese often confront countless obstacles when communicating in English, especially in opening a conversation. In view of helping learners of English overcome these difficulties, this article aims at finding out similarities and differences in ...
My*, H. T. (Hoàng)
core
Introduction: Opening the Conversation on Access [PDF]
This issue opens with a reflection on the urgent theme of access in the humanities and continues with essays that address inequities, pedagogy, and global classrooms, alongside creative and experimental contributions that expand the possibilities of teaching medieval studies today.
Incifem Sari Tekin, Victoria Craggs
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Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source

