Results 81 to 90 of about 392,157 (303)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Le métro parisien en période pandémique : le privilège de l'immobilité
, 2021 La pandémie du Covid-19 a largement impacté nos mobilités quotidiennes depuis mars 2020. Les confinements successifs, les injonctions au télétravail, les changements de programmes d'activités Conversation proposée par : Olivier Finance Université de ...
Cybergeo Conversation
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2020 https://www.westminster.ac.uk/news/dr-manal-mohammed-for-the-conversation-about-which-kinds-of-sanitisers-are-most-effective ...
Mohammed, M.
core +3 more sources
Theology in ScotlandThe Second Vatican Council (1962–65) set out a new vision of the role of lay people in the Roman Catholic Church whereby they were no longer seen as passive recipients of clerical initiatives, but as active ministers of the Gospel. This article describes the historical context from which Vatican II emerged and outlines the scale and significance of the
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2018 From 1956, when he first published, to his passing on 20 February 2018, the teaching and publications of this Professor Emeritus had a major impact on several generations of geographers and cartographers.
Cybergeo Conversation
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The ‘questionableness’ of things: opening up the conversation [PDF]
, 2016 The authors show, through its structure and form, what it means to open up a collaborative conversation. This chapter developed from a number of conversations that took place at the Fourth International Conference on Value and Virtue in Practice-Based Research, the twin themes of which were 'openness' and 'criticality'.
Nixon, J. +5 more
openaire +1 more source