Results 61 to 70 of about 1,961 (282)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Análisis contrastivo y cortesía: “¿El cómo se dice algo es más importante que lo que se dice?”

Revista de Lenguas para Fines Específicos, 2015
Politeness is considered to be a basic orientation in social relationships, it constitutes a significant feature of human behaviour and is connected to a variety of aspects of communication, e.g. gestures and kinesic aspects.
Silvia Betti
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Complaining and arguing in everyday conversation. [PDF]

, 1998
SIGLEAvailable from British Library Document Supply Centre-DSC:DXN021154 / BLDSC - British Library Document Supply CentreGBUnited ...
Dersley, Ian, Dersley, I.
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

“Rush, I Love You”: Interactional Fandom on U.S. Political Talk Radio

International Journal of Communication, 2013
This article analyzes the openings in host-caller interactions in three leading U.S. political talk radio (PTR) programs. Conversation analysis and membership categorization analysis are used to describe how fandom is achieved in these shows.
Gonen Dori-Hacohen
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Open Science: a Shift in the Conversation

, 2019
Keynote talk at the Open Science Fair 2019, Porto, Portugal. Perhaps the most sincere and heart felt talk I have ever given about Open Science. I talk about things like research excellence, and how much damage has already done to science. I express the desire to shift the conversation towards topics like #failtales, mental health, reform of the ...
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Openings of Interactions in Immersive Virtual Reality: Identifying and Recognising Prospective Participants

This chapter studies openings of interactions in immersive virtual reality (VR). Immersive VR refers to computer-generated and visually rich environments that create for the user a powerful sense of immersion.
Tuncer, Sylvaine, Haddington, Pentti, Kohonen-Aho, Laura, Spets, Heidi   +3 more
core   +1 more source