Results 71 to 80 of about 2,534,766 (303)

Predictors of postoperative pain, opioid consumption, and functionality after arthroscopic shoulder surgery: A prospective observational study [PDF]

, 2022
Purpose: This study aims to identify predictors of postoperative pain and opioid consumption after shoulder surgery to help optimize postoperative pain protocols. Study Design: Observational cohort study.
Zeeni, Carine A., Sadek, Nada, Madi, Naji S., Aouad, Marie T., Abou Daher, Layal M., Shebbo, Fadia, Baydoun, Hasan, Al-Taki, Muhyeddine M.   +7 more
core   +1 more source

Impact of Sarcopenia During Induction Treatment in Patients With Unresectable Locally Advanced Pancreatic Cancer

Annals of Gastroenterological Surgery
Background Chemotherapeutic advances have increased opportunities for conversion surgery (CS) in unresectable locally advanced (UR‐LA) pancreatic cancer (PC). However, the optimal indications for CS remain unclear.
Sho Uemura, Masayuki Tanaka, Minoru Kitago, Hiroshi Yagi, Yuta Abe, Yasushi Hasegawa, Shutaro Hori, Yutaka Nakano, Yuko Kitagawa   +8 more
doaj   +1 more source

Successful conversion surgery after comprehensive therapy in a patient with MSI-H but pMMR metastatic gastric mixed adenoneuroendocrine carcinoma: a case report and literature review

Frontiers in Oncology
Gastric mixed adenoneuroendocrine carcinoma (MANEC) is a rare and highly aggressive malignancy characterized by both exocrine and neuroendocrine components. Treatment options for metastatic cases are limited, with typical therapeutic approaches involving
Jun He, Li Wang, Chuanlei Tuo, Chuanlei Tuo, Chuanlei Tuo, Weihua Gong, Yong Liu, Yong Liu, Yong Liu   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Sintilimab plus cisplatin and nab‐paclitaxel induction treatment for locally advanced borderline‐resectable oesophageal squamous cell carcinoma: A single‐arm, prospective, phase 2 study (NEOCRTEC2001)

Clinical and Translational Medicine
Background The standard treatment for locally advanced borderline‐resectable esophageal squamous cell carcinoma (BR‐ESCC) is still debated owing to insufficient evidence from clinical trials.
Jia‐Di Wu, De‐Shen Wang, Zhi‐Qiang Wang, Qiao‐Qiao Li, Bin‐Yang Xu, Chao Ren, Cai‐Yan Fang, Yan Huang, Zhi‐Chao Li, Ji‐Yang Chen, Qiong Tan, Yu‐Hong Li, Hong Yang   +12 more
doaj   +1 more source

Essential updates 2019/2020: Multimodal treatment of localized pancreatic adenocarcinoma: Current topics and updates in survival outcomes and prognostic factors

Annals of Gastroenterological Surgery, 2021
Overall survival of patients with localized pancreatic ductal adenocarcinoma (PDAC) is extremely poor. Therefore, the establishment of multimodal treatment strategies is indispensable for PDAC patients because surgical treatment alone could not ...
Hiroyuki Kato, Akihiko Horiguchi, Masahiro Ito, Yukio Asano, Satoshi Arakawa   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A case of neoadjuvant chemotherapy‐resistant muscle‐invasive bladder cancer that markedly responded to pembrolizumab before conversion radical cystectomy

IJU Case Reports
Introduction Recently, perioperative use of immune checkpoint inhibitors has improved the prognosis of muscle‐invasive bladder cancer. It is unclear whether radical cystectomy or systemic pembrolizumab is the optimal next treatment in patients with ...
Ichiro Yonese, Noboru Numao, Kentaro Inamura, Yusuke Yoneoka, Ryo Fujiwara, Yosuke Yasuda, Tomohiko Oguchi, Shinya Yamamoto, Takeshi Yuasa, Junji Yonese   +9 more
doaj   +1 more source

[Conversion in laparoscopic surgery].

Chirurgia (Bucharest, Romania : 1990), 2003
The conversion causes evaluation in dynamics.The study is a retrospective analysis of the conversion to open surgery in 1993-2001 period, indifferently of the moment and the determinant cause. The yearly dynamics of the conversions was divided by operation types and surgeons.
N, Angelescu, A, Bordea, E, Popa, S, Dragomir, S, Stănilescu, N, Jitea, N, Mircea   +6 more
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source