EBioMedicine, 2023 Summary: Peritoneal metastasis is a challenging aspect of clinical practice for gastric cancer. Animal models are crucial in understanding molecular mechanisms, assessing drug efficacy, and conducting clinical intervention studies, including those ...
Zehui Li +3 more
doaj +3 more sources
From Primary Tumor to Peritoneal Niche: Microenvironmental Divergence in Gastric Cancer Peritoneal Metastasis [PDF]
CellsGastric cancer peritoneal metastasis is not simply an extension of the primary tumor into the abdominal cavity. It represents a biologically distinct disease context shaped by interactions between disseminated tumor cells, peritoneal fluid, mesothelial ...
Catalin-Bogdan Satala +6 more
doaj +2 more sources
Predictors of peritoneal metastasis of gastric origin
Journal of the Egyptian National Cancer Institute, 2022 Background Gastric adenocarcinoma is one of the most aggressive forms of cancer. Despite marked advancements in radiological techniques, peritoneal deposits are still only discovered during laparotomies in a significant number of cases.
Mohamed Atef ElKordy +4 more
doaj +3 more sources
Preoperative clinical-imaging nomogram for peritoneal metastasis in gastric cancer: a retrospective cohort study [PDF]
BMC GastroenterologyObjective To explore the preoperative predictive factors for peritoneal metastasis in patients with advanced gastric cancer and construct a nomogram prediction model combining clinical and radiomics features. Methods A total of 342 patients with advanced
Suxia Qi, Hong Zhang, Yongzhi Lu
doaj +2 more sources
Molecular mediators of peritoneal metastasis in pancreatic cancer [PDF]
Cancer and Metastasis Reviews, 2020 AbstractPancreatic cancer is the third leading cause of cancer death in the USA, and pancreatic ductal adenocarcinoma (PDA) constitutes 85% of pancreatic cancer diagnoses. PDA frequently metastasizes to the peritoneum, but effective treatment of peritoneal metastasis remains a clinical challenge. Despite this unmet need, understanding of the biological
Leela Rani Avula +2 more
exaly +3 more sources
CXCL8 and the peritoneal metastasis of ovarian and gastric cancer
Frontiers in Immunology, 2023 CXCL8 is the most representative chemokine produced autocrine or paracrine by tumor cells, endothelial cells and lymphocytes. It can play a key role in normal tissues and tumors by activating PI3K-Akt, PLC, JAK-STAT, and other signaling pathways after ...
Xuanrong Fu +3 more
doaj +3 more sources
Intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis [PDF]
Gastric Cancer, 2016 Peritoneal metastasis is the most frequent pattern of gastric cancer recurrence or metastasis and is a definitive determinant of prognosis. However, an effective means of treating peritoneal disease has not yet been established. Systemic chemotherapy has only a limited effect on peritoneal metastasis, although some progress has been shown in terms of ...
Yasuhiro Kodera, , Kobayashi Daisuke
exaly +3 more sources
In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation [PDF]
Advanced SciencePeritoneal metastasis is the most lethal manifestation of gastric cancer, with a median survival of less than one year, highlighting the need for new therapeutic targets.
Jie Sun +13 more
doaj +2 more sources
Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction [PDF]
Cell Communication and SignalingBackground Colorectal signet ring cell carcinoma (SRCC) is a rare and aggressive subtype with a high propensity for peritoneal metastasis, yet the underlying mechanisms remain poorly understood.
Weixing Dai +7 more
doaj +2 more sources
Blood ctDNA-specific markers predict the risk of peritoneal metastasis for advanced gastric cancer [PDF]
Discover OncologyObjective The aim of this study was to investigate the value of early postoperative ctDNA dynamic monitoring (TP53/KRAS/PIK3CA gene mutations) combined with clinicopathologic factors in risk stratification of postoperative peritoneal metastasis in ...
FangZhou Xing +5 more
doaj +2 more sources