Results 91 to 100 of about 598,938 (299)
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Stability Aspects in One-Cycle Controlled Buck Converters
Advances in Electrical and Computer Engineering, 2014 The paper aims to investigate issues related to one cycle controlled buck converters stability, in the situation when the integration capacitor discharging is performed through a non-zero value resistor, as it happens in practice.
GURBINA, M., LASCU, D.
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Current-to-frequency converter based on oscillistor effect [PDF]
Омский научный вестникThe possibility of direct current measuring converters construction measuring converted direct current, realizing straightdirect current-to-frequency conversion of current into frequency of alternating current or voltage is considered.
A. I. Cheredov, A. V. Shchelkanov
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Study of Urban Rail Train Renewable Braking Energy Feedback System
机车电传动, 2015 In order to verify the function and reliability of urban rail train renewable energy feedback system, mathematical model of energy feedback converter with double-loop control strategy and SVPWM modulation was built, and the simulation and test were ...
JI Hui, LI Kunpeng, YI Yunlan
doaj
Zeta topology DC/DC converter design based on TPS40200 driver
Российский технологический журналObjectives. The study set out to investigate typical characteristics of a Zeta converter developed by the authors based on the TPS40200 driver under various input voltages and loads and compare the experimental characteristics of the Zeta converter with ...
Vladimir K. Bityukov +2 more
doaj +1 more source
Applied Sciences, 2017 This paper presents and implements a single-stage high-power-factor light-emitting diode (LED) driver with coupled inductors, suitable for streetlight applications.
Chun-An Cheng +4 more
doaj +1 more source