Results 71 to 80 of about 73,148 (266)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Stability Aspects in One-Cycle Controlled Buck Converters
Advances in Electrical and Computer Engineering, 2014 The paper aims to investigate issues related to one cycle controlled buck converters stability, in the situation when the integration capacitor discharging is performed through a non-zero value resistor, as it happens in practice.
GURBINA, M., LASCU, D.
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Applied Sciences, 2017 This paper presents and implements a single-stage high-power-factor light-emitting diode (LED) driver with coupled inductors, suitable for streetlight applications.
Chun-An Cheng +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Study of Urban Rail Train Renewable Braking Energy Feedback System
机车电传动, 2015 In order to verify the function and reliability of urban rail train renewable energy feedback system, mathematical model of energy feedback converter with double-loop control strategy and SVPWM modulation was built, and the simulation and test were ...
JI Hui, LI Kunpeng, YI Yunlan
doaj
Zeta topology DC/DC converter design based on TPS40200 driver
Российский технологический журналObjectives. The study set out to investigate typical characteristics of a Zeta converter developed by the authors based on the TPS40200 driver under various input voltages and loads and compare the experimental characteristics of the Zeta converter with ...
Vladimir K. Bityukov +2 more
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source