Results 51 to 60 of about 73,712 (266)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and Model-Based Evaluation of Active Clamping for Solid-State Circuit Breakers in Vehicular Power Supply Systems

open access: yesIEEE Open Journal of Power Electronics
Solid-state circuit breakers, in vehicles also known as electronic fuses, isolate faults faster than conventional blade fuses and offer advanced protection mechanisms.
Bastian Eisenmann   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Report on laboratory research of power-efficient triple-nozzle tuyere oxygen lancing [PDF]

open access: yesЖурнал інженерних наук, 2017
Based on the analysis of the advantages and shortcomings of the oxygen-converter production in Ukraine with combined oxygen and neutral gas blowing, a new combined-blowing technology by a threelevel lance has been proposed, which privedes the ...
P. O. Yushkevich, L. S. Molchanov
doaj  

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Research on Control Strategy of Electric Mining Dumper Converter

open access: yes机车电传动, 2020
Electric mining dumper has been a key research object in mining industry. Owing to its special operating conditions, the control mode of mining dumper needs to be well studied and selected.
Tao ZHANG, Yaping HE, Xi HE
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Low-Frequency Oscillation Suppression of the Vehicle–Grid System in High-Speed Railways Based on H∞ Control

open access: yesEnergies, 2018
Recently, a traction blockade in the depots of numerous electric multiple units (EMUs) of high-speed railways has occured and resulted in some accidents in train operation.
Zhaozhao Geng   +3 more
doaj   +1 more source

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