Results 111 to 120 of about 249,873 (283)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Review of Converter Circuits with Power Factor Correction

Technologies
This article reviews converter circuits with power factor correction considering issues that arise in implementing such circuits. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) procedure are employed for the review.
Angel Quiroga, Jhon Bayona, Helbert Espitia   +2 more
doaj   +1 more source

Stability of Interconnected DC Converters

, 2015
This paper addresses stability issues of DC networks with constant power loads (CPL). Common DC networks, such as automotive electrical systems and DC microgrids, typically have a step-up/down converter connected in one side to the main bus and, on the ...
Cezar, Gustavo, Rajagopal, Ram, Zhang, Baosen   +2 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Grid-forming Control for Power Converters Based on Hybrid Energy Storage Systems During Islanding Operation [PDF]

Radioengineering
Energy storage systems are increasingly playing a pivotal role in power systems. The combination of distributed sources and energy storage systems with local loads forms an autonomous distribution grid (ADG) capable of flexibly operating in either ...
H. V. Nguyen, C. T. Trinh, G. H. Vu, H. V. Bui, M. D. Nguyen, S. H. Nguyen, C. D. Quach, N. T. Hoang   +7 more
doaj  

Using Nyquist or Nyquist-Like Plot to Predict Three Typical Instabilities in DC-DC Converters

, 2012
By transforming an exact stability condition, a new Nyquist-like plot is proposed to predict occurrences of three typical instabilities in DC-DC converters.
Al-Mothafar, Boiko, Chung-Chieh Fang, El Aroudi, Erickson, Fang, Fang, Fang, Fang, Fang, Giaouris, Hamill, Kazimierczuk, Kuo, Kuznetsov, Lee, Lehman, Maksimovic, Redl, Ridley, Tan, Tse, van der Woude, Wolf, Yuan   +24 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analog-to-digital conversion techniques for precision photometry [PDF]

Three types of analog-to-digital converters are described: parallel, successive-approximation, and integrating. The functioning of comparators and sample-and-hold amplifiers is explained.
Opal, Chet B.
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source