Results 61 to 70 of about 249,873 (283)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analysis and design of a modular multilevel converter with trapezoidal modulation for medium and high voltage DC-DC transformers [PDF]

, 2015
Conventional dual active bridge topologies provide galvanic isolation and soft-switching over a reasonable operating range without dedicated resonant circuits.
Adam, Grain P., Ahmed, Shehab, Gowaid, I. A., Holliday, Derrick, Williams, Barry W.   +4 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A double-sided silicon micro-strip super-module for the ATLAS inner detector upgrade in the high-luminosity LHC [PDF]

, 2014
The ATLAS experiment is a general purpose detector aiming to fully exploit the discovery potential of the Large Hadron Collider (LHC) at CERN. It is foreseen that after several years of successful data-taking, the LHC physics programme will be extended ...
Affolder, A A, Allport, P P, Anghinolfi, F, Barbier, G, Bates, R., Beck, G, Benitez, V, Bernabeu, J, Blanchot, G, Bloch, I, Blue, A., Booker, P, Brenner, R, Buttar, C., Cadoux, F, Carroll, J, Casse, G, Church, I, Civera, J V, Clark, A, Dervan, P, Díez, S, Endo, M, Fadeyev, V, Farthouat, P, Favre, Y, Ferrere, D, French, R, Friedrich, C, Gallop, B, García, C, Gibson, M, Gonzalez-Sevilla, S, Greenall, A, Gregor, I, Grillo, A, Haber, C H, Hanagaki, K, Hara, K, Hauser, M, Haywood, S, Hessey, N, Hill, J, Hommels, L B A, Iacobucci, G, Ikegami, Y, Jones, T, Kaplon, J, Kuehn, S, Lacasta, C, Lynn, D, Mahboubin, K, Marco, R, Marra, D La, Martí-García, S, Martínez-McKinney, F, Matheson, J, McMahon, S, Nelson, D, Newcomer, F M, Parzefall, U, Phillips, P W, Sadrozinski, H F -W, Santoyo, D, Seiden, A, Soldevila, U, Spencer, E, Stanitzki, M, Sutcliffe, P, Takubo, Y, Terada, S, Tipton, P, Tsurin, I, Ullán, M, Unno, Y, Villani, E G, Warren, M, Weber, M, Wilmut, I, Witharm, R, Wonsak, S, Wormald, M   +81 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Nonlinear Analysis and Control of Interleaved Boost Converter Using Real-Time Cycle to Cycle Variable Slope Compensation [PDF]

, 2017
Switched-mode power converters are inherently nonlinear and piecewise smooth systems that may exhibit a series of undesirable operations that can greatly reduce the converter's efficiency and lifetime.
Giaouris, Damian, Ji, Bing, Pickert, Volker, Wu, Haimeng   +3 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Distribution characteristic and formation process of bubbles in foaming slag in a converter

工程科学学报, 2016
Foaming slags at the top at the beginning of deslaggging, in the lower portion at the end of deslagging, and at the bottom after deslagging were taken with a sample scoop at the end of dephosphorization in the converter slag-remaining and double-slag ...
LI Xiang, BAO Yan-ping, WANG Min, LIN Lu
doaj   +1 more source

Comparison of performance and emission characteristics between ceramic and metallic catalytic converter [PDF]

, 2018
Catalytic converters have been widely used on vehicles and have already been proved for many years to be the most effective technical solution to reduce exhaust emissions from gasoline engines where ceramic and metallic catalytic converters are the most ...
W Abdul Rahman, Wan Fakhrurrazi
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source