Results 41 to 50 of about 28,771 (260)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Constant Velocity 3D Convolution

IEEE Access, 2018
We propose a novel 3-D convolution method, cv3dconv, for extracting spatiotemporal features from videos. It reduces the number of sum-of-products operations in 3-D convolution by thousands of times by assuming the constant moving velocity of the features.
Yusuke Sekikawa, Kohta Ishikawa, Hideo Saito   +2 more
doaj   +1 more source

Deep-Learning-Based Multimodal Emotion Classification for Music Videos

Sensors, 2021
Music videos contain a great deal of visual and acoustic information. Each information source within a music video influences the emotions conveyed through the audio and video, suggesting that only a multimodal approach is capable of achieving efficient ...
Yagya Raj Pandeya, Bhuwan Bhattarai, Joonwhoan Lee   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Ramanujan’s Tau-Function and Convolution Sums

European Journal of Theoretical and Applied Sciences
We study certain type of convolution sums involving an arbitrary arithmetic function f, which it is applied to Ramanujan’s tau function when f coincides with the sum of divisors function. 
R., Sivaraman, J., López-Bonilla, J., Yaljá Montiel-Pérez   +2 more
openaire   +1 more source

Convolution of probabilities constant in a subgroup and outside a subgroup

Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika
Let be $P$ the probability on a finite group $G$, i.e. the function $P\left(g\right)$ takes non-negative values and $\sum _{g}P\left(g\right) =1$ $\left(g\in G\right)$.
Oleksandr Vyshnevetskiy
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A Note on Function Spaces with Fractional Fourier Transforms in Wiener-type Spaces

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2023
The purpose of this paper is to introduce and study a function space A_(α,w)^(B,Y) (R^d ) to be a linear space of functions h∈L_w^1 (R^d ) whose fractional Fourier transforms F_α h belong to the Wiener-type space W(B,Y)(R^d ), where w is a Beurling ...
Erdem Toksoy
doaj   +1 more source