Results 51 to 60 of about 292,510 (267)

Optimizing the landscape pattern of blue-green space is more effective than simply increasing the area for cooling effect

Frontiers in Forests and Global Change
BackgroundBlue-Green Space (BGS) is critical for mitigating the Urban Heat Island (UHI) effect amid rapid global urbanization. However, the comparative cooling efficiency of BGS landscape configuration versus simple area expansion remains understudied ...
Guanglong Bao, Xiaohan Sun, Chenchen Fan, Wenwen Li, Xiaoming Li, Fei Yan, Tianran Zhao   +6 more
doaj   +1 more source

How does the ambient environment respond to the industrial heat island effects? An innovative and comprehensive methodological paradigm for quantifying the varied cooling effects of different landscapes

GIScience & Remote Sensing, 2022
Local landscape patterns in cities can substantially alter surrounding land surface temperature (LST) and affect the surface urban heat island effect.
Jianfeng Gao, Qingyan Meng, Linlin Zhang, Die Hu   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Effect of landscaping and greening on microclimate in Hangzhou city

浙江大学学报. 农业与生命科学版, 2001
The effects of greening on temperature and relative humidity are studied. Results show that air temperature is reduced by 0.7℃ on average, 2.3℃ at maximum, and relative humidity increased by 4%on average, 15% at maximum after landscaping and greening in ...
BAO Chun-song, LOU Jian-hua, ZENG Xin-yu, XIANG Zhi-song   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Factors Influencing Spatiotemporal Changes in the Urban Blue-Green Space Cooling Effect in Beijing–Tianjin–Hebei Based on Multi-Source Remote Sensing Data

Land
Owing to rapid urbanization, the Beijing–Tianjin–Hebei region in China faces considerable urban heat island (UHI) effects, which can be mitigated by blue-green space construction. In this study, we used multi-source remote sensing products and the InVEST
Haiying Gong, Yongqiang Cao, Jiaqi Yao, Nan Xu, Huanyu Chang, Shuqi Wu, Liuru Hu, Zihua Liu, Tong Liu, Zihao Zhang   +9 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source