Results 41 to 50 of about 325,229 (311)

Effects of LoD and PoD in combined-hole film cooling [PDF]

, 2017
Film cooling technique was used to provide thermal protection for turbine components from the hot combustion gases. Combined-hole film cooling system was introduced as a way to improve the film cooling performances.
Abdullah, Mohammad Kamil, Hassan, Haswira   +1 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Review of Film Cooling Techniques for Aerospace Vehicles

Energies
Film cooling, a vital method for controlling surface temperatures in components subjected to intense heat, strives to enhance efficiency through innovative technological advancements.
Edidiong Michael Umana, Xiufeng Yang
doaj   +1 more source

Numerical Computation and Optimization of Turbine Blade Film Cooling

Advances in Mechanical Engineering, 2014
The effect of film cooling parameters on the cooling effectiveness of an actual turbine blade is studied numerically. Film cooling parameters such as the hole shape, holes distribution, blowing ratio, streamwise angle, and spanwise angle are investigated
Ahmed M. Elsayed, Farouk M. Owis, M. Madbouli Abdel Rahman   +2 more
doaj   +1 more source

Advances and challenges in commercializing radiative cooling [PDF]

, 2019
Radiative cooling (RC) dissipates terrestrial heat to outer space through the atmospheric window, without external energy input and production of environmental pollutants. More and more efforts have been devoted to this clean promising cooling technology;
Feng, W, Liu, J, Zhang, J, Zhou, Z, Zuo, J   +4 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effects of Turbulence Promoters of Gas Turbine Blades on Film Cooling Performance

Journal of Thermal Science and Technology, 2012
The effects of orientation of turbulence promoting ribs in the internal cooling air passage on the film cooling performance of outer surface of gas turbine blades have been studied experimentally.
Yukiko AGATA, Toshihiko TAKAHASHI, Eiji SAKAI, Koichi NISHINO   +3 more
doaj   +1 more source

Dynamical cooling of galactic discs by molecular cloud collisions -- Origin of giant clumps in gas-rich galaxy discs

, 2017
Different from Milky-Way-like galaxies, discs of gas-rich galaxies are clumpy. It is believed that the clumps form because of gravitational instability.
Li, Guang-Xing
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source