Results 51 to 60 of about 74,264 (312)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Cooling Performance of Impingement–Effusion Double-Wall Configurations Under Atmospheric and Elevated Pressures

Applied Sciences
The combustor liner of the modern aero-engine operates under extreme thermal loads with limited coolant supply, necessarily making efficient cooling approaches important.
Rongxing Zhang, Wei Li, Jianbai Jiang, Xudong Lang, Jinxin Dai, Tianyou Lian, Xiaoxiang Shi, Wei Li   +7 more
doaj   +1 more source

Evaluate the Cooling Effect of Cooling Garments: A Review

Journal of Natural Fibers
Personal cooling garments have the advantages of being highly effective and economically practical, and are widely used in industry, medicine and aerospace. Personal cooling garments exhibit different cooling efficiencies and thermal comfort in different environments due to their different cooling medium characteristics. Air-cooling garments and liquid-
Tian-Hong He, Yan-Ying Ren, Jun-Ying Tian, Ya-Jun Zhou, You-Qi Cheng   +4 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Study of double-wall effusion cooling scheme for gas turbine blade applications

, 2020
Porous multi-wall cooling schemes such as double-wall cooling combined with effusion cooling offer a practical approximation to transpiration cooling which in turn present a potential for high cooling effectiveness.
Ngetich, Gladys Chepkirui
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Control of mineral scaling in power plant recirculating cooling systems using treated municipal wastewater [PDF]

, 2013
The global energy demand is projected to increase by 77% from 2006 to 2030 along with a projected 38% increase in freshwater withdrawal for cooling in power industry. Finding alternative sources of water for cooling has become essential for future energy
Wenshi, Liu
core  

Effects of Turbulence Promoters of Gas Turbine Blades on Film Cooling Performance

Journal of Thermal Science and Technology, 2012
The effects of orientation of turbulence promoting ribs in the internal cooling air passage on the film cooling performance of outer surface of gas turbine blades have been studied experimentally.
Yukiko AGATA, Toshihiko TAKAHASHI, Eiji SAKAI, Koichi NISHINO   +3 more
doaj   +1 more source