Results 51 to 60 of about 328,365 (310)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Different urban heat mitigation strategies are optimal day versus night and for distinct synoptic weather types

Environmental Research: Climate
Extreme heat is projected to increase in frequency and intensity. Commonly applied infrastructure-based urban heat mitigation strategies, including greenery and reflective materials, have the potential to reduce heat exposure.
Sara V Hesse, E Scott Krayenhoff, Abhishek Gaur, Henry Lu, Alberto Martilli   +4 more
doaj   +1 more source

Effect of Inlet Compound Angle of Backward Injection Film Cooling Hole

Energies, 2020
Backward injection film cooling holes were studied to improve film cooling effectiveness using simple cylindrical holes, and this principle was applied to an actual gas turbine.
Yoon Seong Jeong, Jun Su Park
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Review of Film Cooling Techniques for Aerospace Vehicles

Energies
Film cooling, a vital method for controlling surface temperatures in components subjected to intense heat, strives to enhance efficiency through innovative technological advancements.
Edidiong Michael Umana, Xiufeng Yang
doaj   +1 more source

Advances and challenges in commercializing radiative cooling [PDF]

, 2019
Radiative cooling (RC) dissipates terrestrial heat to outer space through the atmospheric window, without external energy input and production of environmental pollutants. More and more efforts have been devoted to this clean promising cooling technology;
Feng, W, Liu, J, Zhang, J, Zhou, Z, Zuo, J   +4 more
core  

Dynamical cooling of galactic discs by molecular cloud collisions -- Origin of giant clumps in gas-rich galaxy discs

, 2017
Different from Milky-Way-like galaxies, discs of gas-rich galaxies are clumpy. It is believed that the clumps form because of gravitational instability.
Li, Guang-Xing
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Numerical Computation and Optimization of Turbine Blade Film Cooling

Advances in Mechanical Engineering, 2014
The effect of film cooling parameters on the cooling effectiveness of an actual turbine blade is studied numerically. Film cooling parameters such as the hole shape, holes distribution, blowing ratio, streamwise angle, and spanwise angle are investigated
Ahmed M. Elsayed, Farouk M. Owis, M. Madbouli Abdel Rahman   +2 more
doaj   +1 more source

Numerical Investigation of the Effects of Lattice Array Structures on Film Cooling Performance

Energies, 2022
To better understand the mechanism influencing the periodic lattice structures in gas turbine blade cooling, these numerical simulations present a systematic comparison of the effects in cases involving pin-fin, Kagome, and BCC lattice arrays on film ...
Qiang Fu, Xiaobo Luo, Wei Chen, Minking K. Chyu   +3 more
doaj   +1 more source