Results 41 to 50 of about 63,450 (264)

Review of Film Cooling Techniques for Aerospace Vehicles

Energies
Film cooling, a vital method for controlling surface temperatures in components subjected to intense heat, strives to enhance efficiency through innovative technological advancements.
Edidiong Michael Umana, Xiufeng Yang
doaj   +1 more source

Effect of Inlet Compound Angle of Backward Injection Film Cooling Hole

Energies, 2020
Backward injection film cooling holes were studied to improve film cooling effectiveness using simple cylindrical holes, and this principle was applied to an actual gas turbine.
Yoon Seong Jeong, Jun Su Park
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Numerical Computation and Optimization of Turbine Blade Film Cooling

Advances in Mechanical Engineering, 2014
The effect of film cooling parameters on the cooling effectiveness of an actual turbine blade is studied numerically. Film cooling parameters such as the hole shape, holes distribution, blowing ratio, streamwise angle, and spanwise angle are investigated
Ahmed M. Elsayed, Farouk M. Owis, M. Madbouli Abdel Rahman   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cooling Performance of Impingement–Effusion Double-Wall Configurations Under Atmospheric and Elevated Pressures

Applied Sciences
The combustor liner of the modern aero-engine operates under extreme thermal loads with limited coolant supply, necessarily making efficient cooling approaches important.
Rongxing Zhang, Wei Li, Jianbai Jiang, Xudong Lang, Jinxin Dai, Tianyou Lian, Xiaoxiang Shi, Wei Li   +7 more
doaj   +1 more source

Evaluate the Cooling Effect of Cooling Garments: A Review

Journal of Natural Fibers
Personal cooling garments have the advantages of being highly effective and economically practical, and are widely used in industry, medicine and aerospace. Personal cooling garments exhibit different cooling efficiencies and thermal comfort in different environments due to their different cooling medium characteristics. Air-cooling garments and liquid-
Tian-Hong He, Yan-Ying Ren, Jun-Ying Tian, Ya-Jun Zhou, You-Qi Cheng   +4 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source