Results 61 to 70 of about 328,365 (310)

Experimental and simulation study on the effect of geometrical and flow parameters for combined-hole film cooling [PDF]

, 2016
Film cooling method was applied to the turbine blades to provide thermal protection from high turbine inlet temperatures in modern gas turbines. Recent literature discovers that combining two cylindrical holes of film cooling is one of the ways to ...
Hassan, Haswira
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Cooling Performance of Impingement–Effusion Double-Wall Configurations Under Atmospheric and Elevated Pressures

Applied Sciences
The combustor liner of the modern aero-engine operates under extreme thermal loads with limited coolant supply, necessarily making efficient cooling approaches important.
Rongxing Zhang, Wei Li, Jianbai Jiang, Xudong Lang, Jinxin Dai, Tianyou Lian, Xiaoxiang Shi, Wei Li   +7 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Evaluate the Cooling Effect of Cooling Garments: A Review

Journal of Natural Fibers
Personal cooling garments have the advantages of being highly effective and economically practical, and are widely used in industry, medicine and aerospace. Personal cooling garments exhibit different cooling efficiencies and thermal comfort in different environments due to their different cooling medium characteristics. Air-cooling garments and liquid-
Tian-Hong He, Yan-Ying Ren, Jun-Ying Tian, Ya-Jun Zhou, You-Qi Cheng   +4 more
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Effects of Turbulence Promoters of Gas Turbine Blades on Film Cooling Performance

Journal of Thermal Science and Technology, 2012
The effects of orientation of turbulence promoting ribs in the internal cooling air passage on the film cooling performance of outer surface of gas turbine blades have been studied experimentally.
Yukiko AGATA, Toshihiko TAKAHASHI, Eiji SAKAI, Koichi NISHINO   +3 more
doaj   +1 more source

Continuous quantum error correction by cooling

, 2005
We describe an implementation of quantum error correction that operates continuously in time and requires no active interventions such as measurements or gates. The mechanism for carrying away the entropy introduced by errors is a cooling procedure.
G. J. Milburn, M. A. Nielsen, Mohan Sarovar, P. Facchi, P. Facchi   +4 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source