Results 61 to 70 of about 325,229 (311)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Experimental study effect of diameter and number of spray nozzle holes on counterflow cooling tower to improve cooling effectiveness

open access: yesMATEC Web of Conferences, 2018
The cooling system is an essential part of the production process within the plant. In the cooling system using cooling tower, efficiency can be improved by increasing the effectiveness of cooling through nozzle modification. This study aims to determine
Fahruddin A'rasy   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Numerical Investigation on Film Cooling Mechanism with Different Coolant Delivery Configurations

open access: yesJournal of Applied Fluid Mechanics, 2021
Kidney vortex has significant impact on film cooling effectiveness, and different kinds of film cooling hole geometry and configuration are developed to weaken or eliminate kidney vortex.
Y. T. Jiang   +4 more
doaj  

Comparison of cooling effectiveness of turbine vanes with and without film cooling [PDF]

open access: yes
The cooling effectiveness of three film-cooled vanes were compared to the cooling effectiveness of two non-film-cooled vanes. The comparison indicated that, for the vane configurations and test conditions examined, film cooling had an adverse effect near
Gauntner, D. J.   +3 more
core   +1 more source

Continuous quantum error correction by cooling

open access: yes, 2005
We describe an implementation of quantum error correction that operates continuously in time and requires no active interventions such as measurements or gates. The mechanism for carrying away the entropy introduced by errors is a cooling procedure.
G. J. Milburn   +4 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Analysis of Modern Numerical Approaches to Film Cooling Simulation on a Flat Surface: Trends, Errors and Correlation Dependencies

open access: yesJournal of Mechanical Engineering
An analysis of modern numerical methods for film cooling simulation on a flat surface, considering current CFD (Computational Fluid Dynamics) trends during 2019–2025, is presented in the paper. More than 25 recent studies devoted to 3D CFD simulations of
Oleh V. Shevchuk
doaj   +1 more source

Influence of premixed swirl-stabilized flame on the cooling performance of an effusion-cooled combustor liner

open access: yesCase Studies in Thermal Engineering
The impact of premixed swirl-stabilized flame on the cooling performance of an effusion-cooled combustor liner perforated by cylindrical and fan-shaped holes is investigated under varying blowing ratios.
Xiang Lu   +3 more
doaj   +1 more source

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