Results 61 to 70 of about 1,073,601 (348)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Simulations of Jet Heating in Galaxy Clusters: Successes and Challenges
, 2018 We study how jets driven by active galactic nuclei influence the cooling flow in Perseus-like galaxy cluster cores with idealised, non-relativistic, hydrodynamical simulations performed with the Eulerian code ATHENA using high-resolution Godunov methods ...
Faucher-Giguere, Claude-Andre +3 more
core +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Static CCT Curve Measurement and Microstructure Analysis of 18CrNiMo7-6 Steel [PDF]
TeshugangThe continuous cooling expansion curve of 18CrNiMo7-6 wind power steel was tested by using a Gleeble-3800 thermal simulator at a cooling rate of 0.1-30 ℃/s.
Lu Feng, Zhang Pei, Li Qi, Qiu Guoxing
doaj +2 more sources
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Metals, 2022 Tool steel for hot working is usually used for the rolls of conventional twin-roll casters for aluminum alloys. In a vertical high-speed twin-roll caster, copper rolls are used to rapidly solidify the aluminum alloys and to increase the casting speed ...
Toshio Haga, Yukihiro Kurahashi
doaj +1 more source
Cooling a micro-mechanical resonator by quantum back-action from a noisy qubit [PDF]
, 2009 We study the role of qubit dephasing in cooling a mechanical resonator by quantum back-action. With a superconducting flux qubit as a specific example, we show that ground-state cooling of a mechanical resonator can only be realized if the qubit ...
C. Bruder +5 more
core +2 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
Journal of Materials Research and TechnologyThis study aims to investigate the effects of continuous cooling after deformation at 900 °C and isothermal cooling after deformation at 830 °C on the microstructure and mechanical properties of EH420 steel, emphasizing ferrite structure evolution.
Hui Liu +8 more
doaj +1 more source