Results 71 to 80 of about 1,550,810 (307)

Risk-return analysis of clean energy grid project investment based on integrated ISM and Monte Carlo model

EAI Endorsed Transactions on Energy Web
To solve the problem of complex and difficult to quantify factors affecting investment returns and risks in clean energy power grids, this study comprehensively applies the interpretive structural model and Monte Carlo model to the analysis of ...
Shu Li, Junyong Xiang, Rong Li, Duo Wang
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Organization for Economic Cooperation and Development (OECD)

, 2014
The Organization for Economic Cooperation and Development (OECD)The Organization for Economic Cooperation and Development is one of the international bodies set up by the West after World War II. It is responsible for analysing and assessing the..
Technical Centre for Agricultural and Rural Cooperation
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Global Center for Security Cooperation booklet [PDF]

, 2011
Established in October 2007 by the Under Secretary of Defense for Policy (OSD-P), the Global Center for Security Cooperation (GCSC) enhances mission support of the Regional Centers for Security Studies and other security cooperation education and ...

core   +2 more sources

Effect of Grain Size on the Friction-Induced Martensitic Transformation and Tribological Properties of 304 Austenite Stainless Steel

Metals, 2020
Friction and wear performance of austenite stainless steels have been extensively studied and show a close relationship with the friction-induced martensitic transformation.
Bo Mao, Shuangjie Chu, Shuyang Wang
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Evaluation of Sida’s Model for Bilateral Research Cooperation

, 2020
The purpose of the evaluation is to provide an overall assessment of the extent to which Sida’s model for bilateral research cooperation builds research capacity in low-income countries. The assessment will serve as input to the in-depth review for
Chou, Panith, Åström, Fredrik, Tostensen, Arne, Bisiaux, Raphaëlle, Pain, Adam, Paz, Rodrigo, Ngugi, Catherine, Tvedten, Inge   +7 more
core  

Norm emergence in tag-based cooperation [PDF]

, 2010
In multi-agent systems norms are an important influence that can engender cooperation by constraining actions and binding groups together. A key question is how to establish a suitable set of norms in a decentralised population of self-interested agents,
Griffiths, N, Luck, M; id_orcid, Griffiths, Nathan, Luck, Michael (Michael M.)   +3 more
core  

Knowledge Production, Area Studies and Global Cooperation [PDF]

, 2017
Whereas Area Studies and cross-border cooperation research conventionally demarcates groups of people by geographical boundaries, individuals might in fact feel more connected by shared values and principles than by conventional spatial dimensions ...
Derichs, Claudia
core   +1 more source