Results 81 to 90 of about 1,550,810 (307)

Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain injury

EMBO Molecular Medicine
Brain injury is the leading cause of mortality among patients who survive cardiac arrest (CA). Clinical studies have shown that the presence of post-CA hypoxic hepatitis or pre-CA liver disease is associated with increased mortality and inferior ...
Zhiyong Guo, Meixian Yin, Chengjun Sun, Guixing Xu, Tielong Wang, Zehua Jia, Zhiheng Zhang, Caihui Zhu, Donghua Zheng, Linhe Wang, Shanzhou Huang, Di Liu, Yixi Zhang, Rongxing Xie, Ningxin Gao, Liqiang Zhan, Shujiao He, Yifan Zhu, Yuexin Li, Björn Nashan, Schlegel Andrea, Jin Xu, Qiang Zhao, Xiaoshun He   +23 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Farm gate profitability of organic and conventional farming systems in the tropics

International Journal of Agricultural Sustainability
Systematic studies on the economic competitiveness of organic farming systems compared to conventional farming systems are particularly lacking in tropical environments.
Amritbir Riar, Eva Goldmann, David Bautze, Johanna Rüegg, Gurbir S. Bhullar, Noah Adamtey, Monika Schneider, Beate Huber, Laura Armengot   +8 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Uncommon Mechanism of Mangled Lower Limb Trauma: Case Report of Salvaged Leg Post Gear Box Explosion Injury

Clinical Case Reports
Mangled limb injuries, typically caused by high‐energy trauma, present significant challenges in surgical decision‐making, particularly when considering limb salvage versus primary amputation.
Khalifa Al Alawi, Iman Zaher, Asim Al Baraznji, Ali Darwiche, Mohammed Muneer   +4 more
doaj   +1 more source

MODELING THE MARKETING COMPONENT OF THE INNOVATIVE CAPACITY OF ORGANIZATIONS ON THE BASIS OF STATISTICAL RESEARCH

Статистика и экономика, 2016
The article considers the General scheme of the modeling process of marketing theinnovation pillar, is an attempt to summarize and systematize approaches tomodel building innovative capacity of organizations on the basis of the marketingconcept, the ...
Anna A. Aletdinova, Yuliya A. Makurina
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

An intelligent early warning method for spatio-temporal deep network considering cascading fault effects in distribution networks

Diance yu yibiao
Cascading faults are prone to cause significant risk of instability hazards to the distribution network system due to the dependency between its components, and eventually lead to the complete collapse of the whole network. Considering that early warning
FANG Zhengji, PAN Kaiyan, KONG Mingzhu, LIU Hua, ZHAO Hongrui, LIU Hongda   +5 more
doaj   +1 more source