Results 51 to 60 of about 1,180,485 (310)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Knowledge Production, Area Studies and Global Cooperation [PDF]

open access: yes, 2017
Whereas Area Studies and cross-border cooperation research conventionally demarcates groups of people by geographical boundaries, individuals might in fact feel more connected by shared values and principles than by conventional spatial dimensions ...
Derichs, Claudia
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Fan (Fiction) Acting on Media and the Politics of Appropriation

open access: yesMedia and Communication, 2017
Fanfiction is the creative appropriation and transformation of existing popular media texts by fans who take stories, worlds and/or characters as starting points and create their own stories based on them.
Wolfgang Reißmann   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Asia-Pacific Model of Development Cooperation [PDF]

open access: yes
Part One of the Osaka Action Agenda has clarified the implications of the basic political commitment to free and open trade and investment in the Bogor Declaration and has set out operational guiding principles and a well-developed strategy of ...
Foundation for Development Cooperation
core   +1 more source

Problems and ways of development of economy of cooperation in the agricultural sector of the region

open access: yesПутеводитель предпринимателя, 2020
The article provides suggested approaches for socio-economic development of the system of consumer cooperation in the agro-industrial complex of Russia, in particular the model and shape the further development of consumer cooperatives and directions of ...
S. V. Biryukova   +2 more
doaj  

Catastrophe and Cooperation [PDF]

open access: yesDynamic Games and Applications, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Pim Heijnen, Lammertjan Dam
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Educating Higher Education Students for Innovative Economies: What International Data Tell Us

open access: yesTuning Journal for Higher Education, 2014
As innovation increasingly fuels economic growth, higher education institutions and systems face the challenge of equipping students with the skills required by innovative economies.
Francesco Avvisati   +2 more
doaj   +1 more source

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