Results 71 to 80 of about 9,964,947 (304)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Programming multi-agent systems [PDF]
, 2015 With the significant advances in the area of autonomous agents and multi-agent systems in the last decade, promising technologies for the development and engineering of multi-agent systems have emerged.
Sub Intelligent Systems +3 more
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the ageing of constituent networks [PDF]
, 2008 The analysis of network topology and dynamics is increasingly used for the description of the structure, function and evolution of complex systems.
Huba J. M. Kiss +6 more
core
The softfoot pro at the cybathlon: kinematic, metabolic, and user performance evaluation
Journal of NeuroEngineering and RehabilitationBackground Prosthetic feet are essential for restoring independent mobility in individuals with lower-limb loss. However, most commercial prosthetic feet rely on elastic elements and rigid, flat soles, limiting adaptability to uneven terrain and ...
Simone Mora +6 more
doaj +1 more source
Cooperative Cooperation: Being, Doing, and Becoming
RAC: Revista de Administração Contemporânea, 2020 Context: the consolidation of an economic system based on competition has not eliminated the importance of cooperation for life in society, or the continuing emergence of cooperative organizations, even in a hostile environment.
Susana Iglesias Webering
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Cooperation in Industrial Systems
, 1991 ARCHON is an ongoing ESPRIT II project (P-2256) which is approximately half way through its five year duration. It is concerned with defining and applying techniques from the area of Distributed Artificial Intelligence to the development of real-size ...
Jennings, N. R.
core +1 more source
IEEE Open Journal of the Communications SocietyOpen RAN has emerged as a transformative approach in the evolution of cellular networks, addressing challenges posed by modern applications and high network density.
Mohamad Wani +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source