Results 71 to 80 of about 1,768,532 (298)
Health system design and performance: what can other countries learn from the Nordic experience? [PDF]
, 2016 Nordic health systems are amongst the strongest in the developed world. This paper discusses their strengths and lessons for other health systems under five headings: sources of finance, provider payment, organization, regulation, and persuasion.
Smith, PC
core +3 more sources
Vertical fit of water governing systems: A regional assessment
Current Research in Environmental SustainabilityTo promote environmentally sustainable water governance, this study emphasizes the necessity of aligning institutional structures with ecological scales. The research focused on the Urmia Lake Basin in Iran facing the serious problem of drying up. Beyond
Peyman Arjomandi A. +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Cooperative database systems [PDF]
International Journal of Intelligent Systems, 1998 In recent years, there has been considerable interest in techniques that enhance the cooperative behavior of database systems and many different techniques have been developed. These techniques approach the goal of cooperation in diverse ways ; the differences may be in the specific task in which they offer cooperation, in the details of the solution ...
openaire +1 more source
A cooperative group optimization system [PDF]
Soft Computing, 2013 A cooperative group optimization (CGO) system is presented to implement CGO cases by integrating the advantages of the cooperative group and low-level algorithm portfolio design. Following the nature-inspired paradigm of a cooperative group, the agents not only explore in a parallel way with their individual memory, but also cooperate with their peers ...
Xie, Xiao-Feng +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Making GATT Dolphin-Safe: Trade and the Environment [PDF]
, 1992 The Swedish municipalities have traditionally, as suppliers of gas, electricity and district heating to end-use consumers, been one of the key actors of national energy politics.
Ross, David J.
core +1 more source
Cooperative Systems Design [PDF]
The Computer Journal, 1994 This paper discusses an innovative experiment where sociologists were actively involved in the requirements analysis for an interactive software system to support the work of air traffic controllers. Air traffic control is intrinsically cooperative and our work involved an analysis of that process from a social perspective and the development of a ...
openaire +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source