Results 41 to 50 of about 944 (214)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Cooperative equity financing and cooperative R&D between competitors
International Review of Economics & FinanceMany firms often face a shortage of R&D funds and have to raise capital by selling ownership shares to their competitors, which affects the R&D models of competing firms.
Fuhai Nie
doaj +1 more source
Marketing Resource Allocation Strategy Optimization Based on Dynamic Game Model
Journal of Mathematics, 2022 Game theory has become an important tool to study the competition between oligopolistic enterprises. After combing the existing literature, it is found that there is no research combining two-stage game and nonlinear dynamics to analyze the competition ...
Yan Long, Hongshan Zhao
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Feedback Equilibrium for Dynamic Competitive and Cooperative Advertising
Procedia Computer Science, 2019 Abstract This paper not only studies the competitive advertising between the manufacturer in direct channel and the upstream retailer which is in distribution channel, but also investigates the cooperative advertising between the upstream manufacturer and the downstream retailer in distribution channel in the case that the downstream retailer faces a
Shigui Ma +3 more
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
MathematicsThis paper investigates cooperative advertising decisions in production–retailing channels for seasonal products under demand seasonality. We develop analytical game-theoretic models to examine how advertising cooperation influences channel coordination ...
Yao-Hung Hsieh +2 more
doaj +1 more source
Distributed Analytical Formation Control and Cooperative Guidance for Gliding Vehicles
International Journal of Aerospace Engineering, 2020 This paper addresses the analytical formation control and cooperative guidance problem for multiple hypersonic gliding vehicles under distributed communication.
Shengwei Jia +3 more
doaj +1 more source
The State As a Non-Cooperative Equilibrium [PDF]
, 1990 We propose a theory of the origin of the State as an institution originating from the voluntary interaction among decentralized and fully informed agents.
Delbono, Flavio, Fiorentini, Gianluca
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source