Results 71 to 80 of about 770,270 (269)

The Homocoupling Reaction of Aromatic Terminal Alkynes by a Highly Active Palladium(II)/AgNO3 Cocatalyst in Aqueous Media Under Aerobic Conditions

Molecules, 2016
A new and efficient Pd(II)/AgNO3-cocatalyzed homocoupling of aromatic terminal alkynes is described. Various symmetrical 1,4-disubstituted-1,3-diynes are obtained in good to excellent yields.
Mengping Guo, Bo Chen, Meiyun Lv, Xiuling Zhou, Yongju Wen, Xiuli Shen   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

PREDOMOS study, impact of a social intervention program for socially isolated elderly cancer patients: study protocol for a randomized controlled trial

Trials, 2017
Background Cancer incidence and social isolation increase along with advanced age, and social isolation potentiates the relative risk of death by cancer.
Elodie Crétel-Durand, Emilie Nouguerède, Hervé Le Caer, Frédérique Rousseau, Frédérique Retornaz, Olivier Guillem, Anne-Laure Couderc, Laurent Greillier, Emmanuelle Norguet, Maud Cécile, Rabia Boulahssass, Francoise Le Caer, Sandrine Tournier, Chantal Butaud, Pierre Guillet, Sophie Nahon, Laure Poudens, Sylvie Kirscher, Sandrine Loubière, Nadine Diaz, Jean Dhorne, Pascal Auquier, Karine Baumstarck   +22 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Global research trends in the teacher evaluation of medical college: A bibliometric and visualized study

Heliyon
Background: The evaluation of education in colleges and universities is not only an essential means to promote teachers' professional development and ensure high-quality development of education but also a strong support for the overall development of ...
Yan Song, Yanpeng Jin, Sifan Wang, Jianan Liu, Yanhan Duan, Haoyang Chen, Haijiang Wu   +6 more
doaj   +1 more source

Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study

BMC Nephrology, 2019
Background Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate
Sachimi Kubo, Yoko Nishida, Yoshimi Kubota, Aya Higashiyama, Daisuke Sugiyama, Takumi Hirata, Naomi Miyamatsu, Ayumi Tanabe, Aya Hirata, Yukako Tatsumi, Aya Kadota, Kazuyo Kuwabara, Tomofumi Nishikawa, Yoshihiro Miyamoto, Tomonori Okamura   +14 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Various Sizes and Shapes of Mixed-Anion Fe(NH₂trz)₃(BF₄)_2−x(SiF₆)_x/2@SiO₂ Nanohybrid Particles Undergoing Spin Crossover Just Above Room Temperature

Nanomaterials
Spin crossover (SCO) iron (II) coordination compounds in the form of nanohybrid SCO@SiO2 particles were prepared using a reverse micelles technique based on the TritonX-100/cyclohexane/water ternary system.
Xinyu Yang, Rafal Bielas, Vincent Collière, Lionel Salmon, Azzedine Bousseksou   +4 more
doaj   +1 more source