Results 71 to 80 of about 760,657 (269)

Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study

BMC Nephrology, 2019
Background Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate
Sachimi Kubo, Yoko Nishida, Yoshimi Kubota, Aya Higashiyama, Daisuke Sugiyama, Takumi Hirata, Naomi Miyamatsu, Ayumi Tanabe, Aya Hirata, Yukako Tatsumi, Aya Kadota, Kazuyo Kuwabara, Tomofumi Nishikawa, Yoshihiro Miyamoto, Tomonori Okamura   +14 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

PREDOMOS study, impact of a social intervention program for socially isolated elderly cancer patients: study protocol for a randomized controlled trial

Trials, 2017
Background Cancer incidence and social isolation increase along with advanced age, and social isolation potentiates the relative risk of death by cancer.
Elodie Crétel-Durand, Emilie Nouguerède, Hervé Le Caer, Frédérique Rousseau, Frédérique Retornaz, Olivier Guillem, Anne-Laure Couderc, Laurent Greillier, Emmanuelle Norguet, Maud Cécile, Rabia Boulahssass, Francoise Le Caer, Sandrine Tournier, Chantal Butaud, Pierre Guillet, Sophie Nahon, Laure Poudens, Sylvie Kirscher, Sandrine Loubière, Nadine Diaz, Jean Dhorne, Pascal Auquier, Karine Baumstarck   +22 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Global research trends in the teacher evaluation of medical college: A bibliometric and visualized study

Heliyon
Background: The evaluation of education in colleges and universities is not only an essential means to promote teachers' professional development and ensure high-quality development of education but also a strong support for the overall development of ...
Yan Song, Yanpeng Jin, Sifan Wang, Jianan Liu, Yanhan Duan, Haoyang Chen, Haijiang Wu   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Various Sizes and Shapes of Mixed-Anion Fe(NH₂trz)₃(BF₄)_2−x(SiF₆)_x/2@SiO₂ Nanohybrid Particles Undergoing Spin Crossover Just Above Room Temperature

Nanomaterials
Spin crossover (SCO) iron (II) coordination compounds in the form of nanohybrid SCO@SiO2 particles were prepared using a reverse micelles technique based on the TritonX-100/cyclohexane/water ternary system.
Xinyu Yang, Rafal Bielas, Vincent Collière, Lionel Salmon, Azzedine Bousseksou   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Amazonian understory forests change phosphorus acquisition strategies under elevated CO2

Nature Communications
The potential for the Amazon forest to continue functioning as a carbon (C) sink strongly depends on soil nutrient availability, particularly phosphorus (P), and on plants’ ability to adjust nutrient acquisition strategies.
Nathielly P. Martins, Lucia Fuchslueger, Laynara F. Lugli, Oscar J. Valverde-Barrantes, Richard J. Norby, Iain P. Hartley, Izabela Aleixo, Fabricio B. Baccaro, Barbara N. S. Brum, Crisvaldo Cássio Silva de Souza, Carine M. Cola, Raffaello Di Ponzio, Amanda Damasceno, Tomas F. Domingues, Vanessa R. Ferrer, Katrin Fleischer, Sabrina Garcia, Alacimar Guedes, Florian Hofhansl, David M. Lapola, Juliane G. Menezes, Anna C. M. Moraes, Ana Caroline Miron, Leonardo Ramos de Oliveira, Cilene Palheta, Iokanam S. Pereira, Maria Pires Martins, Gyovanni Ribeiro, Jéssica Schmeisk-Rosa, Anja Rammig, Flavia D. Santana, Yago R. Santos, Lara Siebert Silva, Bruno Takeshi T. Portela, Gabriela Ushida, Carlos A. Quesada   +35 more
doaj   +1 more source