Results 121 to 130 of about 183,103 (313)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Synthesis and characterization of some metal complexes of tetracycline, theophylline and cimetidine

Discover Chemistry
Metal complexes of tetracycline, cimetidine, theophylline, 1, 10-phenanthroline, 2, 2-bipyridine, and imidazole were synthesized via direct reaction of the respective ligands with selected metal salts, namely copper(I) bromide, cobalt carbonate, and ...
Tunde Samuel Adewale, Olufunso O. Abosede   +1 more
doaj   +1 more source

Synthesis and Characterisation of Cycloaurated Gold(III) Complexes with Bidentate (O,O), (N,S) and (S,S) Chelating Ligands

, 2012
The reaction of C,N-coordinated gold(III) dihalides; BpAuCl₂ (Bp = 2 benzylpyridyl), AnpAuCl₂ (Anp = 2 anilinopyridyl) and TypAuCl₂ (Typ = 2 tolylpyridyl) with catecholate ligands in hot methanol and trimethylamine produced metallacycles with structural ...
Smith, Tiffany Sharee
core  

Interactions of trivalent lanthanide cations with a new hexadentate di-Schiff base : new lanthanide(III) complexes from (NE,N ' E)-2,2 '-(ethane-1,2-diylbis(oxy))bis(N-(pyridin-2-ylmethylene)ethanamine)

, 2010
This research was cofunded by the European Union in the framework of the program “Heraklitos” of the “Operational Program for Education and Initial Vocational Training” of the 3rd Community Support Framework of the Hellenic Ministry of Education, funded ...
Konstantina Skorda, Woollins, J. Derek, Plakatouras, John C., Yang Li, Skorda, Konstantina, Tsiouri, Mantha, Mantha Tsiouri, Christos Papadimitriou, Papadimitriou, Christos, Li, Yang, J. Derek Woollins, John C. Plakatouras   +11 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Copper(II) complexes with 1-methyltetrazole: new method for synthesis and properties

Журнал Белорусского государственного университета: Химия, 2017
A new approach for synthesis of copper(II) complexes with 1-methyltetrazole based on oxidative dissolution of metallic powdercopper in ethanol – HCl (ammonium thiocyanate) was developed. Composition and structure of the complexes prepared were studied by
Andrey N. Bogatikov, Mikhail M. Degtyarik, Oleg A. Ivashkevich   +2 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Synthesis of Functional Metallosupramolecular Complexes

This thesis describes three areas of research which involve preparation of novel pyridyl-thiazole-containing ligands and the formation of their complexes with transition metal ions.
Cox, Nicola Michelle
core  

Coordination polymers utilizing N-oxide functionalised host ligands

, 2012
Pyridyl functionalized host molecules are oxidized to their N-oxide analogues and form a series of coordination polymers and discrete complexes with transition metal cations.
Hardie, Michaele J., Barnett, S.A., James J. Henkelis, Sarah A. Barnett, Harding, L.P., Hardie, M.J., Henkelis, James J., Michaele J. Hardie, Barnett, Sarah A., Henkelis, J.J., Lindsay P. Harding, Harding, Lindsay P.   +11 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source