Results 131 to 140 of about 183,103 (313)

How vanadium and manganese compounds impact cardiac mitochondrial function

Frontiers in Chemical Biology
IntroductionVanadium and manganese are two biologically relevant redox-active first row transition metals. Both metals have been associated with protective and deleterious effects in the cardiovascular system depending on the biological context, chemical
Connor C. Dolan, Luke A. Whitcomb, Edgar Del Carpio, Edgar Del Carpio, Lilliana Rose, Adam J. Chicco, Debbie C. Crans, Debbie C. Crans   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Unveiling Electrochemical Frontiers: Enhanced Hydrazine Sensing with Na₃[Fe(CN)₅(PZT)] Modified Electrodes

Inorganics
This study presents the synthesis, electrochemical characterization, and sensor application of Na3[Fe(CN)5(PZT)], a novel pentacyanidoferrate-based coordination compound incorporating 2-pyrazinylethanethiol (PZT) as a ligand. Unlike conventional Prussian
Kalil Cristhian Figueiredo Toledo, Juliano Alves Bonacin   +1 more
doaj   +1 more source

Síntese, caracterização e estudos cinéticos de complexos de cobre(II) com ligantes triazínicos como modelos biomiméticos da metaloenzima catecol oxidase [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2014.A influência da segunda esfera de coordenação principalmente na eficiência catalítica de ...
Silva, Marcos Paulo da
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Spin-crossover in metal complex-promoted homogenous catalysis

Frontiers in Chemistry
Spin crossover (SCO) is a well-established phenomenon by which transition-metal complexes can reversibly switch between low- and high-spin states, a phenomenon widely studied in materials chemistry.
Lu Huang, Jean-Pierre Djukic
doaj   +1 more source

Metal Coordination Complexes as Redox Mediators in Regenerative Dye-Sensitized Solar Cells

, 2019
Dye-sensitized solar cells (DSSCs) have attracted a substantial interest in the last 30 years for the conversion of solar power to electricity. An important component is the redox mediator effecting the transport of charge between the photoelectrode and ...
Nick Vlachopoulos, Natalie Flores-Díaz, Vlachopoulos, Nick, Stojanovic, Marko, Anders Hagfeldt, Marko Stojanovic, Hagfeldt, Anders, Michael Grätzel, Zakeeruddin, Shaik M., Saygili, Yasemin, Yasemin Saygili, Shaik M. Zakeeruddin, Flores-Diaz, Natalie, Shaik M. Zakeeruddin, Graetzel, Michael   +14 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Complexity Matching in Collaborative Coordination.

, 2018
Complexity matching—converging temporal correlations measured by correlating the slopes of power spectra—is a new measure of coordination based on information exchange between complex networks. To date, studies have focused on the dyadic case, but complexity matching may generalize to interacting complex networks in the left and right hemispheres of a ...
Schloesser, Daniel S, Munoz, Alma G, Kello, Christopher T   +2 more
openaire   +1 more source

Complexes to coordinate calcium

The Journal of Cell Biology, 2005
![Graphic][1] EGFR (small dots) and IP3R1 (large dots) colocalize at PM–ER junctions.On [page 657][2], Hur et al. show that signaling complexes on the plasma membrane and ER, and two different signals, unite to coordinate calcium release.Many signaling pathways, sometimes ...
openaire   +2 more sources