Results 141 to 150 of about 183,103 (313)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Conformationally dynamic copper coordination complexes. [PDF]

Dalton Trans, 2022
Charette BJ, Griffin PJ, Zimmerman CM, Olshansky L.   +3 more
europepmc   +1 more source

Dithiodipropionate and Fumarate Ni, Cu, and Zn Mixed Ligand Complexes

Three nickel, copper, and zinc complexes with dicarboxylic acids (3,3′-dithiodipropionic acid (H2dtdp) and fumaric acid (H2fu)) and N-donor ligands (1,10-phenanthroline (phen), N′–methyldipropylenetriamine (mdpta), and N,N,N′,N ...
Pavel Kopel, Ivana Císařová, Lucie Hochvaldová, Aleš Panáček, Marcin Świątkowski, Ivana Loubalová, Peter Antal, Kamil Kotrle   +7 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Liposomal MRI probes containing encapsulated or amphiphilic Fe(III) coordination complexes. [PDF]

Biomater Sci, 2023
Chowdhury MSI, Kras EA, Turowski SG, Spernyak JA, Morrow JR.   +4 more
europepmc   +1 more source

Synthesis and Coordination Chemistry of Ligands for Supramolecular Chemistry and Sensing Applications

A series of multidentate N-donor ligands have been synthesised all containing pyridyl and pyridyl/thiazole units and their coordination behaviour is described.
Clayton, Hayley J.
core  

Ahmed Hussein, F. A. Devillanova, F. Isaia, G. Verani Copper(I) complexes with N-methylbenzothiazole-2-thione and -2-selone. Transit. Metal Chem., 1985, 10, 368.

, 1985
N-methylbenzothiazole-2-thione (bttme) and -2-selone (btseme) form complexes with CuX 2 (X=Cl, Br, NO 3, 1/2SO 4 or BF 4). The reaction, carried out in MeOH, produces complexes of copper(I), whose stoichiometry mainly depends on the ligand.
F. A. Devillanova, G. Verani Copper complexes with N. methylbenzothiazole 2 thione, ISAIA, FRANCESCO, 2 selone, Ahmed Hussein   +4 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Coordination Complexes Built from a Ditopic Triazole-Pyrazole Ligand with Antibacterial and Antifungal Performances. [PDF]

Molecules, 2023
Draoui Y, Radi S, El Massaoudi M, Bahjou Y, Ouahhoud S, Mamri S, Ferbinteanu M, Benabbes R, Wolff M, Robeyns K, Garcia Y.   +10 more
europepmc   +1 more source