Results 61 to 70 of about 2,881,033 (356)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Solvothermal synthesis, crystal structure and photoluminiscence of Cd(II) coordination polymer derived from a 1,2,3-triazole-based tricarboxylate ligand

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry
A new polymeric complex of cadmium(II) was synthesized under solvothermal conditions by the reaction of 5-(4-carboxy-5-methyl-1H-1,2,3-triazol-1-yl) isophthalic acid (H3L) with cadmium nitrate tetrahydrate in a mixture of N,N-dimethylacetamide and water.
Viorina Gorincioi, Sergiu Sova, Olga Culicova, Gheorghe Roman, Vasile Lozan   +4 more
doaj   +1 more source

Crystal structure of catena-poly[[(N,N-diethyl-3-mesitylsulfonyl-1H-1,2,4-triazole-1-carboxamide-κN1)silver(I)]-μ-nitrato-κ3O,O′:O]

Acta Crystallographica Section E: Crystallographic Communications, 2016
The reaction of silver nitrate and cafenstrole (N,N-diethyl-3-mesitylsulfonyl-1H-1,2,4-triazole-1-carboxamide), a triazole herbicide, leads to the title coordination polymer, [Ag(NO3)(C16H22N4O3S)]n, whose asymmetric unit comprises one cafenstrole ligand
Hyunjin Park, Eunjin Kwon, Il Yoon, Jineun Kim   +3 more
doaj   +1 more source

Coordination Polymer Networks: An Alternative to Classical Polymers? [PDF]

Macromolecular Symposia, 2010
AbstractThis chapter provides a brief overview on metal ion containing coordination polymer networks, how and why they are made, as an alternative to classical polymers. Our focus will be polymorphism, supramolecular isomerism and pseudo‐polymorphism. Examples from our group of metal ion containing coordination polymer networks with flexible molecules ...
Fromm, Katharina M., Sagué, Jorge L., Mirolo, Laurent   +2 more
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Synthesis, Crystal Structure, and Luminescent Property of a Cd(II) Coordination Polymer with a N-Nicotinoylglycine Ligand

Crystals, 2017
A new 1D Cd(II) coordination polymer, [{CdL2(H2O)}·(H2O)3]n (HL = N-nicotinoylglycine), has been synthesized by the assembly of Cd(NO3)2·4H2O with N-nicotinoylglycine, and its composition was determined by elemental analysis, infrared, and X-ray single ...
Xi-Shi Tai, Xin Wang, Peng-Fei Li
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Design and Structural Investigation, Hirschfeld Surface Analysis, and Photoluminescent Behavior of a Cd(II) Coordination Polymer With 4-Acetylphenoxyacetic Acid Ligand

Journal of Spectroscopy
In this study, we successfully designed and synthesized a novel one-dimensional Cd(II) coordination polymer, [CdL3]n [HL = 4-acetylphenoxyacetic acid], employing 4-acetylphenoxyacetic acid as both a chelating and bridging ligand.
Wang Li-Hua, Yan Xi-Hai, Tai Xi-Shi, Saud I. Al-Resayes, Mohammad Azam   +4 more
doaj   +1 more source