Results 61 to 70 of about 87,077 (317)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Coordination polymers utilizing N-oxide functionalised host ligands
, 2012 Pyridyl functionalized host molecules are oxidized to their N-oxide analogues and form a series of coordination polymers and discrete complexes with transition metal cations.
Hardie, Michaele J. +11 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of SpectroscopyIn this study, we successfully designed and synthesized a novel one-dimensional Cd(II) coordination polymer, [CdL3]n [HL = 4-acetylphenoxyacetic acid], employing 4-acetylphenoxyacetic acid as both a chelating and bridging ligand.
Wang Li-Hua +4 more
doaj +1 more source
Macedonian Journal of Chemistry and Chemical Engineering, 2019 In this study, two new coordination polymers of Cu(II) and Cd(II) ions with pyrazine-2,3-dicarboxylic acid and 1-vinylimidazole were synthesized.
Semih Gorduk, Hakan Yilmaz, Omer Andac
doaj +1 more source
Porphyrin-Cored Polymer Nanoparticles: Macromolecular Models for Heme Iron Coordination
, 2016 Porphyrin-cored polymer nanoparticles (PCPNs) were synthesized and characterized to investigate their utility as heme protein models. Created using collapsible heme-centered star polymers containing photodimerizable anthracene units, these systems afford
Kyle J. Rodriguez (3119862) +23 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
, 2021 The design of highly electron-active and stable heterogeneous catalysts for ambient nitrogen reduction reaction is challenging due to the inertness of N2 molecule.
Yuming, Gu +8 more
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Coordination Polymer Nanofibers Generated by Microfluidic Synthesis
, 2016 One-dimensional coordination polymer nanostructures are an emerging class of nanoscale materials with many potential applications. Here, we report the first case of coordination polymer nanofibers assembled using microfluidic technologies.
Daniel Maspoch (473881) +5 more
core +1 more source