Retromer protein VPS29 plays a crucial and positive role in the sumoylation system mediated by E3 SUMO ligase SIZ1. [PDF]
Min WK +11 more
europepmc +1 more source
Cryptochrome 1 promotes photomorphogenesis in Arabidopsis by displacing substrates from the COP1 ubiquitin ligase. [PDF]
Trimborn L +8 more
europepmc +1 more source
Integrated transcriptomic and metabolomic analyses reveal light-quality-dependent regulation of specialized metabolism in Pseudostellaria heterophylla. [PDF]
Tang L +6 more
europepmc +1 more source
PIF4-dependent 2-hydroxymelatonin and 3-hydroxymelatonin biosynthesis is involved in skotomorphogenic seedling growth in Arabidopsis thaliana. [PDF]
Lee HY, Back K.
europepmc +1 more source
Reflection report COP1 : March25-26, 2014, Straubing
Coninx, I., Kranendonk, R.P.
openaire +1 more source
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Promotion of photomorphogenesis by COP1
Plant Molecular Biology, 2004CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) represses photomorphogenesis in darkness by targeting nuclear-localized transcription factors to proteasome-mediated degradation. Upon light exposure, COP1 migrates to the cytosol allowing photomorphogenesis to proceed but the residual nuclear pool down-regulates light signaling mediated by phytochrome A.
Hernán E, Boccalandro +4 more
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Dissecting the functions of
SUMMARYCOP1 is a critical repressor of plant photomorphogenesis in darkness. However, COP1 plays distinct roles in the photoreceptor UVR8 pathway in Arabidopsis thaliana. COP1 interacts with ultraviolet B (UV‐B)‐activated UVR8 monomers and promotes their retention and accumulation in the nucleus.
Qianwen Zhang +6 more
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Spotlight on the role of COP1 in tumorigenesis
Nature Reviews Cancer, 2012COP1 is an E3 ubiquitin ligase that is involved in the ubiquitylation of various protein substrates to trigger their proteasomal degradation. Although originally identified in a light signalling pathway in plants, biochemical studies have identified putative targets of mammalian COP1 with relevant roles in tumorigenesis, including the oncoproteins JUN ...
Jean-Christophe Marine
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