Results 181 to 190 of about 12,187 (208)
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COP1 – from plant photomorphogenesis to mammalian tumorigenesis
Trends in Cell Biology, 2005The COP1 (constitutive photomorphogenic 1) protein, comprising RING finger, coiled-coil and WD40 domains, is conserved in both higher plants and vertebrates. In plants, COP1 acts as an E3 ubiquitin ligase to repress light signaling by targeting photoreceptors and downstream transcription factors for ubiquitylation and degradation.
Chunling, Yi, Xing Wang, Deng
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Nature Cell Biology, 2000
Light regulates the behaviour of many organisms. New data indicate that the greening of plants is facilitated by light-dependent stabilization of a transcription factor that is rapidly degraded in darkness. Thus, photomorphogenesis joins cell division and circadian rhythm as another critical biological process that is governed by proteolysis.
Deshaies, Raymond J. +1 more
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Light regulates the behaviour of many organisms. New data indicate that the greening of plants is facilitated by light-dependent stabilization of a transcription factor that is rapidly degraded in darkness. Thus, photomorphogenesis joins cell division and circadian rhythm as another critical biological process that is governed by proteolysis.
Deshaies, Raymond J. +1 more
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β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1 [PDF]
Cell, 2015 A variety of signals finely tune insulin secretion by pancreatic β cells to prevent both hyper-and hypoglycemic states. Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion.
Magdalena Paolino +2 more
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AtHDA15 binds directly to COP1 positively regulating photomorphogenesis
Biochemical and Biophysical Research Communications, 2020Reversible histone acetylation and deacetylation play crucial roles in modulating light-regulated gene expression during seedling development. However, it remains largely unknown how histone-modifying enzymes interpose within the molecular framework of light signaling network.
Malona V. Alinsug +2 more
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Another Nuclear Partner for COP1
Science Signaling, 2001Plants adapt to light by modulating gene expression in response to photoreceptor stimulation. COP1 is a nuclear protein that acts downstream of multiple photoreceptors and negatively regulates light-dependent developmental processes, such as hypcotyl elongation and chlorophyll accumulation, by suppressing positive regulators in the nucleus.
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PEDF promotes nuclear degradation of ATGL through COP1
Biochemical and Biophysical Research Communications, 2019Adipose triglyceride lipase (ATGL) plays a compelling role in hepatic lipid turnover and in the pathophysiology of non-alcoholic fatty liver disease. Hepatic ATGL is post-transcriptionally regulated by E3 ubiquitin ligase constitutive photomorphogenic1 (COP1) through polyubiquitylation and proteasomal degradation. However the physiological cue for COP1-
Sougata Niyogi +3 more
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Stabilizing the Transcription Factors by E3 Ligase COP1
Trends in Plant Science, 2017Photomorphogenesis is oppositely regulated by two groups of transcription factors. CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) degrades the positive factors but stabilizes the negative ones to predominantly repress photomorphogenesis. It is known that COP1 degrades substrates as an E3 ligase.
Ying, Pan, Hui, Shi
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The photomorphogenic repressors COP1 and DET1: 20 years later
Trends in Plant Science, 2012COP1 and DET1 are among the first repressors of photomorphogenesis to be identified, more than 20 years ago. Discovery of these repressors as conserved regulators of the ubiquitin-proteasome system has established protein degradation as a central theme in light signal transduction.
On Sun, Lau, Xing Wang, Deng
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Light and COP1 regulate level of overexpressed DET1 protein
Plant Science, 2015de-etiolated 1 (det1) and constitutive photomorphogenic 1 (cop1) were initially identified as constitutively photomorphogenic Arabidopsis mutants, exhibiting light-grown phenotypes in the dark. Subsequently, both were shown to be components of Damaged DNA Binding protein 1 (DDB1)/CULLIN4-type complexes.
Valentina, Ly +4 more
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Abstract IA1: COP1: Tumor suppressor role revealed
Cancer Research, 2012Abstract Proto-oncogenes ETV1, ETV4, and ETV5 belong to the PEA3 family of ETS transcription factors and have been identified recently in prostate cancer chromosomal rearrangements that result in their overexpression. Little is known, however, about their post-translational regulation. Here we show that ETV1, ETV4, and ETV5 interact with
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