Results 31 to 40 of about 5,675 (258)
Frontiers in Immunology, 2020 Neutrophil extracellular traps (NETs) contribute to pathological disorders, and their release was directly linked to numerous diseases. With intravital microscopy (IVM), we showed previously that NETs also contribute to the pathology of systemic ...
Iwona Cichon +4 more
doaj +1 more source
Transcriptional regulation of copper metabolism genes in the liver of fetal and neonatal control and iron-deficient rats [PDF]
, 2014 Acknowledgments The authors’ work is supported by Scottish Government (Rural and Environmental Scientific and Analytical Services). We are grateful to Ms Val Stevens for analytical and technical assistance and to the Biological Resource Facility staff ...
Hayes, Helen +3 more
core +2 more sources
Trafficking mechanisms of P-type ATPase copper transporters
Current Opinion in Cell Biology, 2019 Copper is an essential micronutrient required for oxygen-dependent enzymes, yet excess of the metal is a toxicant. The tug-of-war between these copper activities is balanced by chaperones and membrane transporters, which control copper distribution and availability. The P-type ATPase transporters, ATP7A and ATP7B, regulate cytoplasmic copper by pumping
Cortnie Hartwig +5 more
openaire +3 more sources
The effect of maternal iron deficiency on zinc and copper levels and on genes of zinc and copper metabolism during pregnancy in the rat [PDF]
, 2019 Fe deficiency is relatively common in pregnancy and has both short- and long-term consequences. However, little is known about the effect on the metabolism of other micronutrients.
Cottin, Sarah C. +5 more
core +5 more sources
Rice Heavy Metal P-type ATPase OsHMA6 Is Likely a Copper Efflux Protein
Rice Science, 2020 P1B-type heavy metal ATPases (HMAs) are transmembrane metal-transporting proteins that play a key role in metal homeostasis. We here reported the characterization of rice OsHMA6, a member of the P1B-type ATPase family.
Zou Wenli +5 more
doaj +1 more source
The essential roles of metal ions in insect homeostasis and physiology [PDF]
, 2017 Metal ions play distinct roles in living organisms, including insects. Some, like sodium and potassium, are central players in osmoregulation and ‘blood and guts’ transport physiology, and have been implicated in cold adaptation.
Dow, Julian A.T.
core +1 more source
Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis
Frontiers in Aging Neuroscience, 2013 Over the past two decades there have been significant advances in our understanding of copper homeostasis and the pathological consequences of copper dysregulation.
Jonathon eTelianidis +3 more
doaj +1 more source
Metallochaperones regulate intracellular copper levels. [PDF]
, 2013 Copper (Cu) is an important enzyme co-factor that is also extremely toxic at high intracellular concentrations, making active efflux mechanisms essential for preventing Cu accumulation. Here, we have investigated the mechanistic role of metallochaperones
Adams, Michael +9 more
core +1 more source
MicrobiologyOpen, 2017 The ubiquitous cytoplasmic membrane copper transporting P1B‐1 and P1B‐3‐type ATPases pump out Cu+ and Cu2+, respectively, to prevent cytoplasmic accumulation and avoid toxicity.
Ciro Cubillas +6 more
doaj +1 more source
Crystal structure of a copper-transporting PIB-type ATPase
Nature, 2011 Heavy-metal homeostasis and detoxification is crucial for cell viability. P-type ATPases of the class IB (PIB) are essential in these processes, actively extruding heavy metals from the cytoplasm of cells. Here we present the structure of a PIB-ATPase, a Legionella pneumophila CopA Cu(+)-ATPase, in a copper-free form, as determined by X-ray ...
Gourdon, Pontus Emanuel +6 more
openaire +3 more sources