Results 41 to 50 of about 5,675 (258)

Expression and localization of Menkes and Wilson copper transporting ATPases in human placenta

Placenta, 2004
Copper is an essential trace element necessary for normal growth and development. During pregnancy, copper is transported from the maternal circulation to the fetus by mechanisms which have not been clearly elucidated. Two copper transporting ATPases, Menkes (ATP7A; MNK) and Wilson (ATP7B; WND) are known to be expressed in the placenta and are thought ...
Ackland, Ackland, Aldred, Buiakova, Bull, Camakaris, Casey, Chelly, Danks, Danks, Danks, Danzeisen, Gitlin, Harris, Harris, Hein, Horn, Linder, Mann, McArdle, Menkes, Mercer, Michalczyk, Nandakumaran, Oga, Qian, Qian, Rauch, Roelofsen, Royce, Schaefer, Schaefer, Tanzi, Theophilos, Vulpe, Yamaguchi   +35 more
core   +3 more sources

The N-terminal domains of Bacillus subtilis CopA do not form a stable complex in the absence of their inter-domain linker [PDF]

, 2018
Copper-transporting P-type ATPases, which play important roles in trafficking Cu(I) across membranes for the biogenesis of copper proteins or for copper detoxification, contain a variable number of soluble metal-binding domains at their N-termini.
Achila, Arnesano, Banci, Banci, Banci, Banci, Cater, Cobine, Delaglio, DeLano, Fan, Fatemi, Geoffrey R. Moore, Gonzalez-Guerrero, Gonzalez-Guerrero, Gourdon, Huang, Jayakanthan, Kay, Kippen, Kristine L. Kay, Liang Zhou, Lutsenko, Lutsenko, Lutsenko, Lutsenko, Mandal, Mondol, Morin, Nick E. Le Brun, Oliver Hecht, Richards, Singleton, Singleton, Singleton, Strausak, Tsivkovskii, Voskoboinik, Wu, Yatsunyk, Yu, Yu, Zhou, Zhou, Zhou   +44 more
core   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity [PDF]

Proceedings of the National Academy of Sciences, 2006
Menkes disease, a fatal neurodegenerative disorder resulting in seizures, hypotonia, and failure to thrive, is due to inherited loss-of-function mutations in the gene encoding a copper-transporting ATPase (Atp7a) on the X chromosome. Although affected patients exhibit signs and symptoms of copper deficiency, the mechanisms resulting in ...
Michelle L. Schlief, Tim West, Ann Marie Craig, David M. Holtzman, Jonathan D. Gitlin   +4 more
openalex   +3 more sources

Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: Emerging roles [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Copper (Cu) has a role in a diverse and increasing number of pathways, physiological and disease processes. These roles are testament to the fundamental importance of Cu in biology and the need to understand the mechanisms that regulate Cu homeostasis.
Sharon La Fontaine, M. Leigh Ackland, Julian F. B. Mercer   +2 more
openalex   +4 more sources

Advances in the molecular understanding of biological zinc transport [PDF]

, 2015
Between 5 and 10% of all proteins of a given organism are estimated to require zinc for function, and hence zinc is essential for almost any given metabolic process. It is therefore of great interest to understand major players and mechanisms that ensure
Blindauer, Claudia A.
core   +1 more source

P1B P-type ATPases: Cu+-ATPases in GtoPdb v.2023.1 [PDF]

, 2023
Copper-transporting ATPases convey copper ions across cell-surface and intracellular membranes. They consist of eight TM domains and associate with multiple copper chaperone proteins (e.g. ATOX1, O00244)
Lutsenko, Svetlana
core   +2 more sources

Pathogenic adaptations to host-derived antibacterial copper [PDF]

, 2014
Recent findings suggest that both host and pathogen manipulate copper content in infected host niches during infections. In this review, we summarize recent developments that implicate copper resistance as an important determinant of bacterial fitness at
Chaturvedi, Kaveri S, Henderson, Jeffrey P   +1 more
core   +3 more sources

EPR Methods for Biological Cu(II): L-Band CW and NARS [PDF]

, 2015
: Copper has many roles in biology that involve the change of coordination sphere and/or oxidation state of the copper ion. Consequently, the study of copper in heterogeneous environments is an important area in biophysics. EPR is a primary technique for
Bennett, Brian, Kowalski, Jason M.
core   +2 more sources

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity [PDF]

Journal of Biological Chemistry, 2009
Copper is an essential micronutrient that is necessary for healthy immune function. This requirement is underscored by an increased susceptibility to bacterial infection in copper-deficient animals; however, a molecular understanding of its importance in immune defense is unknown.
White, Carine, Lee, Jaekwon, Kambe, Taiho, Fritsche, Kevin, Petris, Michael J.   +4 more
openaire   +2 more sources