Results 51 to 60 of about 75,676 (211)
Mitochondrial-ER Contact Sites and Tethers Influence the Biosynthesis and Function of Coenzyme Q
ContactCoenzyme Q (CoQ) is an essential redox-active lipid that plays a major role in the electron transport chain, driving mitochondrial ATP synthesis. In Saccharomyces cerevisiae (yeast), CoQ biosynthesis occurs exclusively in the mitochondrial matrix via a ...
Noelle Alexa Novales +4 more
doaj +1 more source
Coenzyme Q10 deficiencies: pathways in yeast and humans. [PDF]
, 2018 Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant.
Awad, Agape M +5 more
core
Animal Models and Experimental Medicine, EarlyView.We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang +14 more
wiley +1 more source
Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
AntioxidantsCoenzyme Q10 (CoQ) is a ubiquitous lipid with different biological functions. In blood, there is a close relationship between CoQ status and cholesterol, which strongly supports the study of both molecules simultaneously.
Beatriz Minguez +12 more
doaj +1 more source
The Anatomical Record, EarlyView.Abstract Macaws are renowned for processing dry, mechanically resistant fruits, yet the species‐level anatomical and functional correlates of this performance remain incompletely resolved. We examined the feeding apparatus of the Blue‐and‐yellow Macaw (Ara ararauna) using an integrated approach that combines osteology, myology, and bite‐force estimates
Sérgio R. Posso +2 more
wiley +1 more source
Type classes for efficient exact real arithmetic in Coq [PDF]
, 2013 Floating point operations are fast, but require continuous effort on the part of the user in order to ensure that the results are correct. This burden can be shifted away from the user by providing a library of exact analysis in which the computer ...
Krebbers, Robbert, Spitters, Bas
core +2 more sources
Environmental Policy and Governance, EarlyView.ABSTRACT The sound formation of robust environmental policies is increasingly important for low‐ and middle‐income countries (LMICs) to achieve their national objectives and international commitments. However, policy implementation can be complex, and environmental policies may not be prioritised given other critical socio‐economic development issues ...
Rebecca K. M. Clube, Julia Tomei
wiley +1 more source
The Rooster and the Syntactic Bracket [PDF]
, 2013 We propose an extension of pure type systems with an algebraic presentation of inductive and co-inductive type families with proper indices. This type theory supports coercions toward from smaller sorts to bigger sorts via explicit type construction, as ...
Herbelin, Hugo, Spiwack, Arnaud
core +8 more sources
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Coenzyme Q supplementation in pulmonary arterial hypertension
Redox Biology, 2014 Mitochondrial dysfunction is a fundamental abnormality in the vascular endothelium and smooth muscle of patients with pulmonary arterial hypertension (PAH). Because coenzyme Q (CoQ) is essential for mitochondrial function and efficient oxygen utilization
Jacqueline Sharp +8 more
doaj +1 more source