Results 71 to 80 of about 75,676 (211)

Persistent Instability in Policy Debates: The Three‐Body Problem of Trade, Agriculture and the Environment

open access: yesJCMS: Journal of Common Market Studies, EarlyView.
Abstract Literature on policy debates often analyses cases involving either a single or two policy fields, which typically result in stable equilibria, manifesting either as outright rejection of policy proposals, successful institutional change or the entrenchment of divisions into a deadlock.
Laure Gosselin   +2 more
wiley   +1 more source

Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects.

open access: yesPLoS ONE, 2010
BackgroundCoenzyme Q(10) (CoQ(10)) and its analogs are used therapeutically by virtue of their functions as electron carriers, antioxidant compounds, or both.
Luis C López   +8 more
doaj   +1 more source

CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression

open access: yesAntioxidants, 2022
Coenzyme Q (CoQ, aka ubiquinone) is a key component of the mitochondrial electron transport chain (ETC) and membrane-incorporated antioxidant. CoQ10 deficiencies encompass a heterogeneous spectrum of clinical phenotypes and can be caused by hereditary ...
Ching-Fang Chang   +6 more
doaj   +1 more source

Automated verification of termination certificates [PDF]

open access: yes, 2012
In order to increase user confidence, many automated theorem provers provide certificates that can be independently verified. In this paper, we report on our progress in developing a standalone tool for checking the correctness of certificates for the ...
Blanqui, Frédéric, Ly, Kim Quyen
core   +2 more sources

Formal Proofs for Nonlinear Optimization [PDF]

open access: yes, 2015
We present a formally verified global optimization framework. Given a semialgebraic or transcendental function $f$ and a compact semialgebraic domain $K$, we use the nonlinear maxplus template approximation algorithm to provide a certified lower bound of
Allamigeon, Xavier   +3 more
core   +4 more sources

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang   +14 more
wiley   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

open access: yesAdvanced Science, Volume 13, Issue 26, 8 May 2026.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen   +12 more
wiley   +1 more source

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans   +8 more
wiley   +1 more source

Effect of a Two-Week Diet without Meat and Poultry on Serum Coenzyme Q10 Levels

open access: yesDietetics
Coenzyme Q10 (CoQ10) is an essential compound for energy production in the mitochondria and the antioxidation of lipid-soluble substances in cells. As it can be biosynthesized in cells, CoQ10 is not an essential nutrient.
Toshikazu Suzuki
doaj   +1 more source

Category Theory in Coq 8.5 [PDF]

open access: yes, 2015
We report on our experience implementing category theory in Coq 8.5. The repository of this development can be found at https://bitbucket.org/amintimany/categories/.
Jacobs, Bart, Timany, Amin
core   +2 more sources

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