Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi [PDF]
Molecules, 2019 Cordycepin (3′-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value.
Minrui Liu
exaly +6 more sources
Molecular Mechanisms of Temperature-Regulated Cordycepin Biosynthesis in Cordyceps militaris [PDF]
Journal of FungiCordycepin is a key active component of Cordyceps militaris, but the molecular mechanism underlying temperature-regulated biosynthesis remains unclear. In this study, Cordyceps militaris strain KN-1 was used as experimental material, with low-temperature
Jiaxing Shao +7 more
doaj +3 more sources
Neutral Lipid Content in Lipid Droplets: Potential Biomarker of Cordycepin Accumulation in Cordycepin-Producing Fungi [PDF]
Molecules, 2019 To clarify the relationship between neutral lipid content and cordycepin accumulation in Cordyceps militaris, mutants were generated from mixed spores of two C. militaris strains with varying cordycepin-producing capacities.
Peng Qin +9 more
doaj +4 more sources
Mechanism of Activation of AMPK by Cordycepin [PDF]
Cell Chemical Biology, 2020 Cordycepin (3'-deoxyadenosine) is a major bioactive agent in Cordyceps militaris, a fungus used in traditional Chinese medicine. It has been proposed to have many beneficial metabolic effects by activating AMP-activated protein kinase (AMPK), but the mechanism of activation remained uncertain.
Hawley, Simon A. +5 more
openaire +5 more sources
Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway
Mediators of Inflammation, 2022 Hepatic ischemia/reperfusion injury (HIRI) is a common complication of liver surgery requiring hepatic disconnection, such as hepatectomy and liver transplantation.
Jiameng Ding +14 more
doaj +2 more sources
Cordycepin Inhibits Virus Replication in Dengue Virus-Infected Vero Cells
Molecules, 2021 Dengue virus (DENV) infection causes mild to severe illness in humans that can lead to fatality in severe cases. Currently, no specific drug is available for the treatment of DENV infection. Thus, the development of an anti-DENV drug is urgently required.
Aussara Panya +9 more
doaj +3 more sources
A Systematic Review of the Biological Effects of Cordycepin [PDF]
Molecules, 2021 We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models.
Masar Radhi +9 more
doaj +4 more sources
The Protective Effect of Cordycepin on D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Injury [PDF]
Mediators of Inflammation, 2017 As the major active ingredient of Cordyceps militaris, cordycepin (3′-deoxyadenosine) has been well documented to alleviate inflammation and oxidative stress both in vitro and in vivo. To explore the potential protective effect of cordycepin in fulminant
Jin Li +3 more
doaj +2 more sources
Development of Cordycepin Formulations for Preclinical and Clinical Studies [PDF]
AAPS PharmSciTech, 2017 There is extensive literature on in vivo studies with cordycepin, but these studies were generally conducted without validation of the various formulations, especially in terms of the solubility of cordycepin in the dosing vehicles used. Cordycepin is a promising drug candidate in multiple therapeutic areas, and there is a growing interest in studies ...
Jong Bong Lee +5 more
openaire +4 more sources
IbrainThe aggregation of β‐amyloid (Aβ) peptides has been associated with the onset of Alzheimer's disease (AD) by causing neurotoxicity due to oxidative stress and apoptosis.
Wenshu Zhou +6 more
doaj +2 more sources