Results 21 to 30 of about 5,413 (203)

Cordycepin Decreases Ischemia/Reperfusion Injury in Diabetic Hearts via Upregulating AMPK/Mfn2-dependent Mitochondrial Fusion

Frontiers in Pharmacology, 2021
Diabetes mellitus is considered to be a major risk factor for cardiovascular disease, the most common cause of death in diabetes. However, therapeutic strategies for myocardial protection in patients with diabetes are still limited.
Houyou Yu, Xin Hong, Lihua Liu, Yangpeng Wu, Xuemei Xie, Guoxiang Fang, Shaomin Zhi   +6 more
doaj   +1 more source

Simple Isolation of Cordycepin from Cordyceps militaris by Dual-Normal Phase Column Chromatography and Its Potential for Making Kombucha Functional Products

Separations, 2022
Cordycepin (3′-deoxyadenosine) is a potent bioactive metabolite of the medicinal fungus Cordyceps militaris, which has been increasingly exploited to treat various chronic diseases in humans.
Nguyen Van Quan, Yu Iuchi, La Hoang Anh, Mehedi Hasan, Tran Dang Xuan   +4 more
doaj   +1 more source

Transcriptome Analysis Reveals the Flexibility of Cordycepin Network in Cordyceps militaris Activated by L-Alanine Addition

Frontiers in Microbiology, 2020
Cordycepin, isolated from the traditional medicinal fungus Cordyceps militaris, has gained much attention due to its various clinical functions. Previous reports of L-alanine addition could significantly improve cordycepin production, but the molecular ...
Bai-Xiong Chen, Bai-Xiong Chen, Tao Wei, Tao Wei, Ling-Na Xue, Ling-Na Xue, Qian-Wang Zheng, Qian-Wang Zheng, Zhi-Wei Ye, Zhi-Wei Ye, Yuan Zou, Yuan Zou, Yi Yang, Yi Yang, Fan Yun, Li-Qiong Guo, Li-Qiong Guo, Jun-Fang Lin, Jun-Fang Lin   +18 more
doaj   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof-of-Concept Study. [PDF]

ChemMedChem
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Lowe S, Satikuvar V, Syeda TM, Cal M, Mäser P, Kaiser M, Kadri H.   +6 more
europepmc   +2 more sources

Cordycepin Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Modulation of AMPK and AKT Activation

Pharmaceutics, 2022
Benign prostatic hyperplasia (BPH) is a disease that commonly affects elderly men. Cordycepin is an adenosine analog with a wide range of pharmacological activities including antiproliferative and prostatic smooth muscle relaxant effects.
Abdulmohsin J. Alamoudi, Sami A. Alessi, Waleed Y. Rizg, Abdulmajeed M. Jali, Awaji Y. Safhi, Fahad Y. Sabei, Sameer Alshehri, Khaled M. Hosny, Ashraf B. Abdel-Naim   +8 more
doaj   +1 more source

Blockade of adipocyte differentiation by cordycepin [PDF]

British Journal of Pharmacology, 2012
BACKGROUND AND PURPOSE Cordyceps militaris has the potential to suppress differentiation of pre‐adipocytes. However, the active entities in the extract and the underlying mechanisms of its action are not known. Hence, we investigated whether and how cordycepin (3′‐deoxyadenosine), a constituent of C.
Shuhei, Takahashi, Minori, Tamai, Shotaro, Nakajima, Hironori, Kato, Hisashi, Johno, Tomoyuki, Nakamura, Masanori, Kitamura   +6 more
openaire   +2 more sources

Cordycepin Suppresses The Malignant Phenotypes of Colon Cancer Cells through The GSK3ß/ß-catenin/cyclin D1 Signaling Pathway [PDF]

Cell Journal, 2022
Objective: Cordycepin, also known as 3ˊ-deoxyadenosine, is the main bioactive ingredient of Cordyceps militaris and possesses various pharmacological effects.
Jie Xu, Xia Shen, Daozhong Sun, Yanjie Zhu   +3 more
doaj   +1 more source

Synthesis of 4′-substituted cordycepins [PDF]

Nucleic Acids Symposium Series, 2005
Synthesis of 4'-substituted analogues of cordycepin was carried out. Electrophilic addition of N-iodosuccinimide/benzoic acid to 2',5'-bis-O-(tert-butyldimethyl-silyl)-3',4'-unsaturated adenosine (5) enabled the introduction of a leaving group to the 4'-position.
Yutaka, Kubota, Mayumi, Kunikata, Rumi, Ohsawa, Yuria, Odajima, Kazuhiro, Haraguchi, Hiromichi, Tanaka   +5 more
openaire   +2 more sources

Cordycepin attenuates migration and invasion of HSC-4 oral squamous carcinoma cells through autophagy-dependent FAK/Akt and MMP2/MMP9 suppression

Journal of Dental Sciences, 2022
Background/purpose: Cordycepin has been proposed anti-cancer effects, however, it is unclear whether and how cordycepin affects oral squamous carcinoma cell (OSCC) migration and invasion.
Thunwa Binlateh, Nawapol Uppatcha, Jutamast Thepchai, Yanaphat Pleungtuk, Parinya Noisa, Pilaiwanwadee Hutamekalin, Paiboon Jitprasertwong   +6 more
doaj   +1 more source

Protective effects of cordycepin pretreatment against liver ischemia/reperfusion injury in mice

Immunity, Inflammation and Disease, 2023
Introduction Cordycepin has been reported to exhibit hepatic protective and anti‐inflammatory properties. Here, we investigated the role of cordycepin in ischemia/reperfusion (IR)‐induced liver injury in a mouse model.
Yunxia Liu, Mingwei Sheng, Lili Jia, Min Zhu, Wenli Yu   +4 more
doaj   +1 more source