Results 61 to 70 of about 9,908 (255)

Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm [PDF]

open access: yes, 2006
Speckles are nuclear bodies that contain pre-mRNA splicing factors and polyadenylated RNA. Because nuclear poly(A) RNA consists of both mRNA transcripts and nucleus-restricted RNAs, we tested whether poly(A) RNA in speckles is dynamic or rather an ...
Politz, J. C. R.   +8 more
core   +1 more source

Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway.

open access: yesBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Type 2 diabetes mellitus (T2DM) is a common and multiple endocrine metabolic disease. When pancreatic β cell in case of dysfunction, the synthesis and secretion of insulin are reduced.
Baiyi Yan   +11 more
semanticscholar   +1 more source

Anti‐inflammatory effects of cordycepin: A review

open access: yesPhytotherapy Research, 2020
Cordycepin is the major bioactive component extracted from Cordyceps militaris. In recent years, cordycepin has received increasing attention owing to its multiple pharmacological activities. This study reviews recent researches on the anti‐inflammatory effects and the related activities of cordycepin.
Tan, Lu   +9 more
openaire   +2 more sources

Cordyceps : a traditional chinese medicine and another fungal therapeutic biofactory? [PDF]

open access: yes, 2008
Traditional Chinese medicines (TCM) are growing in popularity. However, are they effective? Cordyceps is not studied as systematically for bioactivity as another TCM, Ganoderma.
Paterson, R. R. M.
core   +1 more source

Susceptibility of Trypanosoma evansi to cordycepin

open access: yesBiomedicine & Pharmacotherapy, 2011
Drugs, which are effective during the early stage of trypanosomosis, but poorly penetrate the blood-brain barrier, are ineffective when parasites reach the brain and cause encephalitis. In order to seek alternative treatments, the aim of this study was to test the susceptibility of T.
Aleksandro S, Da Silva   +10 more
openaire   +2 more sources

Improved Cordycepin Production by Cordyceps militaris KYL05 Using Casein Hydrolysate in Submerged Conditions

open access: yesBiomolecules, 2019
Cordycepin, a beneficial bioactive product specifically found in Cordyceps, has received attention in various bioindustrial applications such as in pharmaceuticals, functional foods, and cosmetics, due to its significant functions.
Soo Kweon Lee   +7 more
doaj   +1 more source

Engineering Komagataella phaffii to biosynthesize cordycepin from methanol which drives global metabolic alterations at the transcription level.

open access: yesSynthetic and Systems Biotechnology, 2023
Cordycepin has the potential to be an alternative to the disputed herbicide glyphosate. However, current laborious and time-consuming production strategies at low yields based on Cordyceps militaris lead to extremely high cost and restrict its ...
Huiping Tan   +8 more
semanticscholar   +1 more source

Cordycepin inhibits colon cancer proliferation by suppressing MYC expression

open access: yesBMC Pharmacology and Toxicology, 2022
Background Cordycepin is a purine nucleoside anti-metabolite and anti-biotic isolated from the fungus Cordyceps militaris, which has potential anti-neoplastic activities. This study aimed to investigate the effect of cordycepin in inhibiting colon cancer
Zhe Zhang, Kui Li, Zhi Zheng, Yu Liu
doaj   +1 more source

Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells

open access: yesMolecules, 2021
Immunotherapy harnessing immune functions is a promising strategy for cancer treatment. Tumor sensitization is one approach to enhance tumor cell susceptibility to immune cell cytotoxicity that can be used in combination with immunotherapy to achieve ...
Suthida Panwong   +6 more
doaj   +1 more source

Cordycepin inhibits vascular smooth muscle cell proliferation

open access: yesEuropean Journal of Pharmacology, 2008
Percutaneous transluminal coronary angioplasty (PTCA) is a common procedure for treating atherosclerosis, but its efficacy is limited because of the occurrence of restenosis within 3-6 months after angioplasty. Restenosis is induced by the remodeling of the vessel wall and/or the accumulation of cells and extracellular matrix (ECM) in the intimal layer.
Woochul, Chang   +8 more
openaire   +3 more sources

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