Results 31 to 40 of about 5,889,855 (232)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Element 4 Assessment Plan with Final Report Template Core General Education Assessment, 2023-2024

, 2023
The Assessment Plan with Final Report Template for Element 4 - Arts/Humanities as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core   +1 more source

Element 2 Chairs and Course List Core General Education Assessment, 2019-2020

, 2020
The Chairs and Course List for Element 2 - Mathematics as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

SICAS, a new integrated divertor-SOL-pedestal-core framework for self-consistent modeling of ion and impurity transport in fusion devices

Nuclear Fusion
We present a new framework for core-edge integration studies named SICAS (SOLPS-ITER coupled to ASTRA-STRAHL) which enables high fidelity simulations of the core, edge, and divertor regions encompassing the transport of ions as well as the impurities ...
A. Welsh, L. Casali, E. Fable, J. Smiskey, R. Mattes, G. Tardini, B.T. Taczak   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Modeling electron temperature profiles in the pedestal with simple formulas for ETG transport

Nuclear Fusion
This paper reports on the refinement (building on (Hatch D.R. et al 2022 Phys. Plasmas 29 062501)) and application of simple formulas for electron heat transport from electron temperature gradient (ETG) driven turbulence in the pedestal. The formulas are
D.R. Hatch, M.T. Kotschenreuther, P.-Y. Li, B. Chapman-Oplopoiou, J. Parisi, S.M. Mahajan, R. Groebner   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

On the relationship between the H-mode separatrix density and engineering parameters across multiple tokamaks: physics-based models, regression, and extrapolations to next-step devices

Nuclear Fusion
The electron density at the separatrix ( $n_{\mathrm{e},\mathrm{sep}}$ ) plays a central role in balancing energy confinement, detachment achievement, and edge-localized mode suppression in tokamaks, thereby influencing core-edge integration.
D. Silvagni, O. Grover, A. Stagni, J.W. Hughes, M.A. Miller, B. Lomanowski, L. Balbinot, G. Ciraolo, W. Dekeyser, M. Dunne, L. Frassinetti, C. Giroud, T. Happel, I. Jepu, A. Kallenbach, A. Kirjasuo, A. Kuang, T. Luda, D. Moulton, O. Pan, C. Perez von Thun, T. Pütterich, G. Rubino, S.A. Silburn, H.J. Sun, D. Umezaki, H. Zohm, the ASDEX Upgrade Team, JET Contributors, the EUROfusion Tokamak Exploitation Team   +29 more
doaj   +1 more source