Results 31 to 40 of about 150,909 (276)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Towards self-consistent integrated modeling of the tokamak pedestal, scrape-off layer, and divertor using SOLPS-ITER and EPED

Nuclear Fusion
A predictive, self-consistent integrated model of the tokamak edge plasma and neutral system has been developed and validated against experimental data from DIII-D, spanning from the divertor target and scrape-off layer to the top of the pedestal.
R.S. Wilcox, J.M. Canik, J.M. Park, P.B. Snyder, M.W. Shafer, S. De Pascuale, D.C. Easley, A.W. Leonard, J.D. Lore, A.G. McLean, A.L. Moser, J.S. Park, H.Q. Wang   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Simultaneous ELM suppression and divertor detachment via synergistic boron powder and neon injection in EAST

Nuclear Fusion
A novel approach for simultaneous power exhaust and edge-localized mode (ELM) control is presented in the Experimental Advanced Superconducting Tokamak discharges, which utilize an ITER-like tungsten divertor.
Zhen Sun, Rajesh Maingi, Wei Xu, Lei Peng, Kedong Li, Xin Lin, Yunxin Cheng, Donggui Wu, Fang Ding, Zhe Wang, Yanhong Guan, Minrui Wang, Yan Chao, Qingquan Yang, Kaifu Gan, Yuqiang Tao, Alessandro Bortolon, Huiqian Wang, Tianfu Zhou, Jia Huang, Wei Wang, Yifei Jin, Yanmin Duan, Yanzhen Xu, Ahmed Diallo, Kevin Tritz, Alexander Nagy, Hanna Schamis, Guizhong Zuo, Jinping Qian, Xianzu Gong, Jiansheng Hu, the EAST Team   +32 more
doaj   +1 more source

Advanced operation modes relying on core plasma turbulence stabilization in tokamak fusion devices

AAPPS Bulletin, 2023
Recent progress of advanced operation modes in tokamaks is addressed focusing upon internal transport barrier (ITB) discharges. These ITB discharges are being considered as one of candidate operation modes in fusion reactors.
Yong-Su Na
doaj   +1 more source

On Automatic Reasoning for Schema Integration

, 1993
Success in database schema integration depends on the ability to capture real world semantics of the schema objects, and to reason about the semantics. Earlier schema integration approaches mainly rely on heuristics and human reasoning. In this paper, we
Sheth, Amit P., Gala, Sunit K., Navathe, Shamkant B.   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Edge Center (archived) [PDF]

, 2015
Includes an image of the main page on this date and compressed file containing additional web pages.The Edge Center operates through the Naval Postgraduate School (NPS), with Professor Mark Nissen serving as Director.
Naval Postgraduate School, Naval Postgraduate School (U.S.)   +1 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source