Results 61 to 70 of about 80,540 (232)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Research Advances in Decision-Making Technologies for Precision Pesticide Application in Crops

Agronomy
Global agricultural production is severely threatened by the intensification of crop diseases and pests. Traditional pesticide application methods, characterized by inefficiency and frequent phytotoxicity, necessitate the urgent development of smart ...
Xiaofu Feng, Tongye Shi, Huimin Wu, Mengran Yang, Mengyao Luo, Jiali Li, Changling Wang   +6 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Event-Driven Edge Agent Framework for Distributed Control in Distribution Networks

Energies
With the large-scale integration of heterogeneous energy resources and the increasing demand for flexible control, centralized control is facing challenges in terms of operational efficiency and system responsiveness when handling high-precision ...
Xianglong Zhang, Ying Liu, Songlin Gu, Yuzhou Tian, Yifan Gao   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Synergistic effects of E×B drifts and neutral recycling on core-edge integration for next-step fusion development

Abstract It is increasingly urgent to address core-edge integration issues for the design and construction of next-step fusion devices. Evidence of density shelf has appeared, for the first time, in the HL-2A tokamak with a closed, long-leg divertor configuration for the ion drift toward the magnetic X-point. The density shelf is manifested as
Hailong Du, Hailong Du, Houyang Guo, Na Wu, Huiqian Wang, Xavier Bonnin, Zengchen Yang, Bin Chen, Ze Yan, Dongmei Fan, Yulin Zhou, Lei Xue, Jiaxian Li, Shuo Wang, Miao Xue, Guoyao Zheng, Zhi Huang, Longwen Yan, Jinming Gao, Xiaoquan Ji, wei chen, Wulu Zhong, Min Xu, Dezhen Wang   +23 more
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Deployment and application of “5G+MEC”enabled intelligent manufacturing

Dianxin kexue, 2019
As one of the key techniques of 5G,MEC can localize the application and promote the deep integration of networks and services.In order to realize the application of “5G+MEC” in vertical industry,the 5G core network with service-based architecture was ...
Lingyi KONG
doaj   +2 more sources