Results 61 to 70 of about 672,839 (260)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Integrating Multi-Access Edge Computing (MEC) into Open 5G Core

Telecom
Multi-Access Edge Computing (MEC) represents the central concept that enables the creation of new applications and services that bring the benefits of edge computing to networks and users.
Ruben Xavier, Rogério S. Silva, Maria Ribeiro, Waldir Moreira, Leandro Freitas, Antonio Oliveira-Jr   +5 more
doaj   +1 more source

A theory of the city as object: or, how spatial laws mediate the social construction of urban space [PDF]

, 2001
A series of recent papers (Hillier et al 1993, Hillier 1996b, Hillier 2000) have outlined a generic process by which spatial configurations, through their effect on movement, first shape, and then are shaped by, land use patterns and densities. The aim
Hillier, B.
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

State-of-the-art survey on resource optimization in edge computing

大数据, 2019
The traditional centralized architecture,known as cloud computing,cannot accommodate such user demands in an efficient and timely manner.To cope with this problem,edge computing architectures have been proposed with the core concept of that“data ...
Zhihao QU, Baoliu YE, Guihai CHEN, Bin TANG, Chenghao GUO   +4 more
doaj  

Network Structure and Synergy Characteristics in the Guangdong-Hong Kong-Macao Greater Bay Area

Applied Sciences
In regions where transportation and the economy are closely integrated, optimizing network structure and enhancing synergy are vital for regional integration.
Shaobo Wang, Yafeng Qin, Xiaobo Lin, Zhen Wang, Yingjun Luo   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

HIPED: machine learning framework for spherical tokamak pedestal prediction and optimization

Nuclear Fusion
We introduce a machine learning framework, HIPED (HeIght and width Predictor for Edge Dynamics), for predicting and optimizing pedestal and core performance in spherical tokamak plasmas.
J.F. Parisi, J.G. Clark, J.W. Berkery, C. Bowman, C.J. Fitzpatrick, S.M. Kaye, M. Lampert   +6 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

ESCNet: Edge-Semantics Collaborative Network With Multiscale Fusion for Land Cover Classification

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Land cover classification is a critical task in remote sensing image processing, with its core objective being the accurate classification of surface coverage through pixel-level feature extraction, thereby supporting applications such as environmental ...
Guangqi Xie, Jiawei Hu, Rui Tao, Zhiqi Zhang, Shenggu Yuan   +4 more
doaj   +1 more source