Results 71 to 80 of about 150,909 (276)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Core-edge integrated predictive studies of ST40 and NSTX plasmas with the scrape-off layer box model

Physics of Plasmas
The ability to model the interplay between the core and edge of tokamak plasmas is crucial to designing both the plasma operating scenario of a fusion pilot plant and the design of the tokamak itself. Scrape-off-layer (SOL) models that are tailored to integrated scenario modeling need to have fast turn-around time and minimal computational burden to ...
X. Zhang, N. A. Lopez, E. D. Emdee, F. M. Poli, T. O'Gorman, P. F. Buxton, C. Marsden, M. Moscheni, H. F. Lowe, A. Rengle   +9 more
openaire   +1 more source

Organizational Engagement with Supply Chain Integration: Achieving a Tangible Strategy

, 2015
Although supply chain management and supply chain integration have become topics found within today’s organization as well as topics for researchers from various disciplines, little research has been completed concerning the linkage between business ...
Duffy, Kevin P., Sethi, Vikram, Farmer, Berkwood M., Jeyaraj, Anand   +3 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Automated Disassembly of Waste Printed Circuit Boards: The Role of Edge Computing and IoT

Computers
The ever-growing volume of global electronic waste (e-waste) poses significant environmental and health challenges. Printed circuit boards (PCBs), which form the core of most electronic devices, contain valuable metals as well as hazardous materials. The
Muhammad Mohsin, Stefano Rovetta, Francesco Masulli, Alberto Cabri   +3 more
doaj   +1 more source

EU financial integration : is there a 'Core Europe'? ; evidence from a cluster-based approach [PDF]

, 2004
Numerous recent studies, e.g. EU Commission (2004a), Baele et al. (2004), Adam et al.(2002), and the research pooled in ECB-CFS (2005), Gaspar, Hartmann, and Sleijpen(2003), have documented progress in EU financial integration from a micro-level view ...
Mark Mietzner, Mietzner, Mark, Thomas Kiehlborn, Kiehlborn, Thomas   +3 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Integrating AI and cloud-edge technologies for music creation in educational and performance domains

Journal of Cloud Computing: Advances, Systems and Applications
This paper provides a systematic exploration of Artificial Intelligence (AI) for music generation within a cloud-edge synergy architecture (i.e. a coordinated cloud–edge computing paradigm where the cloud handles compute-intensive training and high ...
Xue Fan, Wei Zou, M. K. Moghimi, Wei Yi
doaj   +1 more source

Research Advances in Decision-Making Technologies for Precision Pesticide Application in Crops

Agronomy
Global agricultural production is severely threatened by the intensification of crop diseases and pests. Traditional pesticide application methods, characterized by inefficiency and frequent phytotoxicity, necessitate the urgent development of smart ...
Xiaofu Feng, Tongye Shi, Huimin Wu, Mengran Yang, Mengyao Luo, Jiali Li, Changling Wang   +6 more
doaj   +1 more source