Results 71 to 80 of about 5,889,855 (232)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Integrating AI and cloud-edge technologies for music creation in educational and performance domains

Journal of Cloud Computing: Advances, Systems and Applications
This paper provides a systematic exploration of Artificial Intelligence (AI) for music generation within a cloud-edge synergy architecture (i.e. a coordinated cloud–edge computing paradigm where the cloud handles compute-intensive training and high ...
Xue Fan, Wei Zou, M. K. Moghimi, Wei Yi
doaj   +1 more source

Automated Disassembly of Waste Printed Circuit Boards: The Role of Edge Computing and IoT

Computers
The ever-growing volume of global electronic waste (e-waste) poses significant environmental and health challenges. Printed circuit boards (PCBs), which form the core of most electronic devices, contain valuable metals as well as hazardous materials. The
Muhammad Mohsin, Stefano Rovetta, Francesco Masulli, Alberto Cabri   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Element 5 Assessment Plan with Final Report Template Core General Education Assessment, 2021-2022

, 2022
The Assessment Plan with Final Report Template for Element 5 - Social Science as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core   +1 more source

OSNet: An Edge Enhancement Network for a Joint Application of SAR and Optical Images

Remote Sensing
The combined use of synthetic aperture radar (SAR) and optical images for surface observation is gaining increasing attention. Optical images, with their distinct edge features, can accurately classify different objects, while SAR images reveal deeper ...
Keyu Ma, Kai Hu, Junyu Chen, Ming Jiang, Yao Xu, Min Xia, Liguo Weng   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Research Advances in Decision-Making Technologies for Precision Pesticide Application in Crops

Agronomy
Global agricultural production is severely threatened by the intensification of crop diseases and pests. Traditional pesticide application methods, characterized by inefficiency and frequent phytotoxicity, necessitate the urgent development of smart ...
Xiaofu Feng, Tongye Shi, Huimin Wu, Mengran Yang, Mengyao Luo, Jiali Li, Changling Wang   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source