Results 91 to 100 of about 9,087,341 (299)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
El decreto de las Cortes de Cádiz del 4 de enero de 1813 y su aplicación en Montevideo
El decreto de las Cortes de Cádiz del 4 de enero de 1813 sobre ocupación productiva de tierras baldías, aunque desconocido por la historiografía rioplatense, fue invocado en Montevideo por Benito Chain para solicitar ese mismo año la donación de unas ...
Fernando Aguerre Core
doaj
Microbial communities play critical roles in various ecosystems. Despite extensive research on the taxonomic and functional diversity of microbial communities, effective approaches to regulate targeted microbial functions remain limited. Here, we present
Shengguo Zhao +9 more
doaj +1 more source
Twelve mature (aged 5–16 years) horses and ponies of mixed breed and type were fed restricted (1.25% BM Dry matter) quantities of one of two fiber based diets formulated to be iso-caloric.
Kirsty Dougal +7 more
doaj +1 more source
Penelitian ini bertujuan untuk melihat perbedaan rata-rata kemampuan koneksi matematis dengan model pembelajaran CORE (connecting, organizing, reflecting, extending) dan model pembelajaran NHT (numbered head together).
Jahring Jahring
doaj +1 more source
Let \(A\) be an associative algebra with unit. The author introduces the concept of a weak \(A\)-coring, where the left and the right structure of module of the coring need not to be unital. The theory of weak corings is related with the weak entwined structures introduced by \textit{S. Caenepeel} and \textit{E. de Groot} [Contemp. Math.
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Topological classification of vortex-core structures of spin-1 Bose-Einstein condensates
We classify vortex-core structures according to the topology of the order parameter space. By developing a method to characterize how the order parameter changes inside the vortex core.
G. E. Volovik +8 more
core +1 more source

