Results 61 to 70 of about 1,302,762 (259)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Utilization of molecular, phenotypic and geographical diversity to develop compact composite core collection in the oilseed crop, Safflower (Carthamus tinctorius L.) through maximization strategy

Frontiers in Plant Science, 2016
Carthamus tinctorius L. is a dryland oilseed crop yielding high quality edible oil. Previous studies have described significant phenotypic variability in the crop and used geographical distribution and phenotypic trait values to develop core collections.
Shivendra Kumar, Heena Ambreen, Murali Tottekkad Variath, Murali Tottekkad Variath, Atmakuri Ramakrishna Rao, Manu Agarwal, Amar Kumar, Shailendra Goel, Arun Jagannath   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Construction of a Core Collection for Morchella Based on Phenotypic Traits from China

Horticulturae
To rationally utilize Morchella germplasm resources, this study investigated 13 phenotypic traits in 231 Chinese Morchella germplasm accessions. Accessions were stratified by cap color and subjected to comparative analyses using four sampling methods ...
Xuelian Cao, Ying Chen, Lixu Liu, Jie Tang, Shishi Liu, Liyuan Xie, Yiping Li   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Molecular characterization of Moroccan grapevine germplasm using SSR markers for the establishment of a reference collection

OENO One, 2009
Aims: This study aims to characterize the SODEA ampelographic collection in Meknès, the only germplasm repository in Morocco. To assess the usefulness of this germplasm, a study was conducted to verify the trueness to type of the genotypes and to provide
Aicha El Oualkadi, Mohammed Ater, Zerhoune Messaoudi, Valérie Laucou, Jean-Michel Boursiquot, Thierry Lacombe, Patrice This   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Genealogical Analysis in the Czech Spring Wheat Collection and its Use for the Creation of Core Collection

Czech Journal of Genetics and Plant Breeding, 2006
A spring wheat collection of the Czech gene bank included altogether 3270 original accessions in 2005; among them 2123 accessions with pedigree were analyzed using the construction of genetic profiles and subsequent calculation of Renkonen similarity ...
Zdeněk Stehno, Iva Faberová, Ladislav Dotlačil, Sergey Martynov, Tatjana Dobrotvorskaya   +4 more
doaj   +1 more source