Results 111 to 120 of about 6,100 (143)

Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation. [PDF]

Sci Rep, 2017
Wang N, Deng Y, Liu A, Shen N, Wang W, Du X, Tang Q, Li S, Odeh Z, Wu T, Lin H.   +10 more
europepmc   +1 more source

<i>N-</i>glycosylation alterations in expressed prostatic secretions: exploring liquid biopsy biomarkers for prostate cancer diagnosis and disease progression. [PDF]

PeerJ
Chew IYY, Jayapalan JJ, Lim J.
europepmc   +1 more source

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Inhibition of core fucosylation limits progression of diabetic kidney disease

Biochemical and Biophysical Research Communications, 2019
FUT8-mediated core fucosylation, which transfers a fucose residue from GDP-fucose to core-GlcNAc of the N-linked type glycoproteins, is crucial for signaling receptors function. Core fucosylation is involved in various biological processes such as cell proliferation, apoptosis, differentiation and immune regulation.
Hongli Lin, Qingzhu Tang
exaly   +3 more sources

Inhibiting core fucosylation attenuates glucose-induced peritoneal fibrosis in rats

Kidney International, 2018
Ultrafiltration failure is a major complication of long-term peritoneal dialysis, resulting in dialysis failure. Peritoneal fibrosis induced by continuous exposure to high glucose dialysate is the major contributor of ultrafiltration failure, for which there is no effective treatment. Overactivation of several signaling pathways, including transforming
Yiyao Deng, Longkai Li, Juan Jesus Carrero   +2 more
exaly   +3 more sources

A fluorogenic probe for core-fucosylated glycan-preferred ENGase

Carbohydrate Research, 2023
A fluorescence-quenching-based assay system to determine the hydrolytic activity of endo-β-N-acetylglucosaminidases (ENGases), which act on the innermost N-acetylglucosamine (GlcNAc) residue of the chitobiose segment of core-fucosylated N-glycans, was constructed using a dual-labeled fluorescent probe with a hexasaccharide structure.
Nozomi Ishii, Hiroshi Muto, Mitsuo Nagata, Kanae Sano, Itsuki Sato, Kenta Iino, Yuji Matsuzaki, Toshihiko Katoh, Kenji Yamamoto, Ichiro Matsuo   +9 more
openaire   +2 more sources

Mechanisms of pulmonary fibrosis induced by core fucosylation in pericytes

The International Journal of Biochemistry & Cell Biology, 2017
Pulmonary fibrosis is a common outcome of a variety of pulmonary interstitial diseases, and myofibroblasts are the main culprit for this process. Recent studies have found that pericytes are one of the major sources of myofibroblasts; the transformation of which involves a complex process of activation of TGF-β/Smad2/3 and PDGFβ/Erk signaling pathways.
Wei, Sun, HaiYing, Tang, Lili, Gao, Xiuna, Sun, Jia, Liu, WeiDong, Wang, Taihua, Wu, Hongli, Lin   +7 more
openaire   +2 more sources

Identification of Core-Fucosylated Glycoproteome in Human Plasma

2017
The core-fucosylated (CF) glycoproteins are widely distributed in mammalian tissues and regulated under pathological conditions, especially in cancer progression. The Food and Drug Administration (FDA) has approved the core-fucosylated α-fetoprotein as a biomarker for the early diagnosis of hepatocellular carcinoma (HCC). An approach for identifying CF
Qichen, Cao, Qing, Zhao, Xiaohong, Qian, Wantao, Ying   +3 more
openaire   +2 more sources

Modular Synthesis of Core Fucosylated N‐Glycans

European Journal of Organic Chemistry, 2012
AbstractA modular synthesis of complex‐type N‐glycans containing the core fucosyl motif was optimized. The core trisaccharide building block was protected by a methoxyphenyl group for convenient core fucosylation. The trisaccharide was obtained on a large scale from the glycosylation of the corresponding chitobiosyl azide with a glucosyl donor followed
Dimitri Ott, Joachim Seifert, Ingo Prahl, Mathäus Niemietz, Joanna Hoffman, Janna Guder, Manuel Mönnich, Carlo Unverzagt   +7 more
openaire   +1 more source

Influence of Core Fucosylation on the Flexibility of a Biantennary N-Linked Oligosaccharide

Biochemistry, 1996
Fluorescence energy transfer was used to study the conformation of each antenna of a complex biantennary oligosaccharide. A core fucosylated biantennary oligosaccharide was converted to a glycosylamine which allowed coupling of a naphthyl donor fluorophore directly to the reducing-end GlcNAc 1.
H J, Stubbs, J J, Lih, T L, Gustafson, K G, Rice   +3 more
openaire   +2 more sources

Distinctive domains and activity regulation of core fucosylation enzyme FUT8

Biochimica et Biophysica Acta (BBA) - General Subjects
Core fucose, a structure added to the reducing end N-acetylglucosamine of N-glycans, has been shown to regulate various physiological and pathological processes, including melanoma metastasis, exacerbation of chronic obstructive pulmonary disease, and severe outcomes in COVID-19.Recent research has shed light on regulation of the activity and ...
Seita, Tomida, Masamichi, Nagae, Yasuhiko, Kizuka   +2 more
openaire   +2 more sources